Results 81 to 90 of about 104,711 (263)
Advanced Intelligent Systems, EarlyView.A hybrid Reinforcement Learning–Explainable AI framework integrates SHAP and LIME explanations directly into a Deep Q‐Network inference loop for real‐time ICU decision support. Trained on 18 142 mechanically ventilated stays from the eICU database, the system attains 93.0% decision accuracy, 20% fewer errors than RL alone, and a 91% clinician trust ...
Jannatul Ferdaus Disha +2 more
wiley +1 more source
Journal of Perioperative NursingThis paper explores the transformative impact of clinical leadership within the perioperative setting of the Australian healthcare system. It details the grassroots advocacy led by perioperative clinicians, particularly nurse practitioners, who invested
Toni Hains, Catherine Smith
doaj +2 more sources
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Detailed clinical phenotypes have been previously reported for 33 individuals with X‐linked HNRNPH2‐related neurodevelopmental disorder. Of these, 75% self‐reported a musculoskeletal abnormality, including hip dysplasia, scoliosis, kyphosis, lordosis, pes planus, arthritis, and missing spinous processes.
Ambar Garcia +6 more
wiley +1 more source
JMIR Formative ResearchBackgroundImmune checkpoint inhibitors are widely used in oncology but can cause immune-related adverse events (irAEs), which may be severe or life-threatening if not detected early.
Julia Lai-Kwon +8 more
doaj +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins +9 more
wiley +1 more source
Agreement of triage decisions between gastroenterologists and nurses in a hospital endoscopy unit
Clinical and Experimental Gastroenterology, 2018 Stephen Inns,1,2 Jeffrey Wong,1 Dena McPhedran,1 Gladys De Guzman,1 Katherine Broome,1 Dalice Sim,2 Rosemarie Sandford1,† 1Hutt Valley DHB Endoscopy Unit, Hutt Valley DHB, Lower Hutt, Wellington, New Zealand; 2Department of Medicine, Otago ...
Inns S +6 more
doaj
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Post‐traumatic stress disorder (PTSD) causes significant mental and physical distress, yet only a small subset of individuals exposed to trauma develop the disorder. Scientists and clinicians are still unable to predict who will get the disorder or how it will manifest.
Brandy M. Fox
wiley +1 more source
Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment
Annals of Neurology, EarlyView.Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring +18 more
wiley +1 more source
ANK1 and EPB41 Variants and The Risk of Glucocorticoid‐Induced Osteonecrosis
Arthritis &Rheumatology, EarlyView.Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen +21 more
wiley +1 more source
A closer look at the role of apology in error disclosure: a simulation study
Frontiers in Health ServicesBackgroundThe importance of open communication following harmful medical errors is widely accepted including the role of authentic apology. Yet, disclosure conversations remain difficult for clinicians and offering an authentic apology is challenging ...
Sarah E. Shannon +9 more
doaj +1 more source