Results 281 to 290 of about 844,807 (370)

Extracellular Vesicular Delta‐Like Ligand 3 and Subtype Transcription Factors for Small Cell Lung Cancer Diagnosis

open access: yesAdvanced Science, EarlyView.
Small cell lung cancer (SCLC) harbors high molecular heterogeneity. Using a new liquid biopsy assay, SCLC subtypes can be identified by measuring mRNA of subtype transcription factors (ASCL1, POU2F3, and NEUROD1) in exosome‐rich extracellular vesicles. Combining with Delta‐like ligand 3 (DLL3) mRNA in exosomes and its membrane protein in extracellular ...
Hong Li   +27 more
wiley   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

open access: yesAdvanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao   +17 more
wiley   +1 more source

Unveiling Salt Tolerance Mechanisms in Plants: Integrating the KANMB Machine Learning Model With Metabolomic and Transcriptomic Analysis

open access: yesAdvanced Science, EarlyView.
Salt stress endangers coastal cereal crops, requiring resilient crop solutions. This study employs machine learning (KANMB) to analyze multi‐omics data from halophyte Spartina alterniflora, revealing 226 salt‐stress biomarkers and linking them to tolerance pathways. The MYB gene SaMYB35 regulates flavonoid biosynthesis under salinity.
Shoukun Chen   +7 more
wiley   +1 more source

Precepting nurse practitioner students in the graduate nurse education demonstration: A cross-sectional analysis of the preceptor experience. [PDF]

open access: yesJ Am Assoc Nurse Pract, 2019
Todd BA   +12 more
europepmc   +1 more source

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

open access: yesAdvanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui   +15 more
wiley   +1 more source

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