Results 131 to 140 of about 661,532 (288)

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

open access: yesAdvanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang   +19 more
wiley   +1 more source

Guiding the Clinical Nurse Specialist role in oncology within Princess Margaret Cancer Centre. [PDF]

open access: yesCan Oncol Nurs J, 2022
Cheung V   +5 more
europepmc   +1 more source

ATTITUDES OF SPECIALIST NURSES TOWARDS DEATH: PARTICULARITIES OF SPECIALIST NURSES IN REHABILITATION NURSING

open access: yesRevista Portuguesa de Enfermagem de Reabilitação, 2020
Objetivo: analisar as diferenças no perfil de atitudes face à morte entre enfermeiros especialistas em enfermagem de reabilitação e enfermeiros especialistas em outras áreas. Método: estudo comparativo, quantitativo, transversal, com participação de 223 enfermeiros especialistas de um hospital do norte de Portugal. Como instrumento de colheita de dados
Cardoso, Maria Filomena Passos Teixeira   +3 more
openaire   +2 more sources

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

open access: yesAdvanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang   +17 more
wiley   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

open access: yesAdvanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma   +11 more
wiley   +1 more source

Research progress of clinical nurse specialist

open access: yesHuli yanjiu, 2005
it introduced research progress of clinical nurse specialists. It expatiated mainly the phylogeny, the role function, the assessment on the value of roles, qualification of certification, problems existed in practice and the status quo of clinical nurse ...
符丽燕, 朱念琼, 康丹
doaj  

AUSPRAC : The Nurse Practitioner Research Toolkit [PDF]

open access: yes, 2010
Chapter 1: Introduction\ud \ud Overview and background\ud \ud Chapter 2: Conducting clinical audit of nurse practitioner practice \ud \ud The nature and purpose of clinical audit--\ud Data collection tools for clinical audit--\ud References and readings ...
Gardner, Glenn E.   +3 more
core   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

open access: yesAdvanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang   +5 more
wiley   +1 more source

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