Results 51 to 60 of about 661,990 (286)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A Study on the Qualifications and Ways of Selecting Candidates of Clinical Nurse Specialist in China
Huli yanjiu, 2003 Objective: to understand the viewpoints of nursing staffs towards the essential qualifications and ways of selecting candidates of clinical nurse specialists in our country, and to provide a basis for the establishment of an eligible criteria for ...
王欣, 王惠珍
doaj
Construction of training program for cardiac rehabilitation specialist nurse
Huli yanjiu, 2023 ObjectiveTo construct the training program for cardiac rehabilitation specialist nurse，so as to provide reference basis for the training of cardiac rehabilitation specialist nurses in China.MethodsThrough literature review and semi-structured interview ...
LIU Shuo +3 more
doaj
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Evaluation of the implementation of the prostate cancer specialist nurse role
, 2015 A national prostate cancer specialist nursing pilot program, supported by Prostate Cancer Foundation of Australia, was launched in May 2012 with funding support from The Movember Foundation.
Langbecker, Danette +2 more
core
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Specializations in nursing: the students' perspective
Obzornik zdravstvene nege, 2015 Introduction: In Slovenia, nursing students and professionals do not yet have the possibility for specialized career development. The aim of the study is to determine the students' plans for their career development and their views on nursing ...
Martin Sever, Branko Bregar
doaj +1 more source
The role of the clinical nurse specialist
, 2001 Aim: To investigate the current work and role of the clinical nurse specialist.Method: Twenty semi-structured interviews were undertaken with clinical nurse specialists and analysed using the constant comparative approach of grounded theory.Results: The ...
McCreaddie, May
core
Practical Nurse Training Course [PDF]
, 1953 Document found on page 18 of "Development of Practical Nursing in Hawaii 1947-1967" ScrapbookBrochure describes the Practical Nurse Training Course, admission requirements, cost of course, course content, and admission ...
Practical Nurse Training Program
core
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source