Results 141 to 150 of about 689,911 (297)

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

open access: yesAdvanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu   +5 more
wiley   +1 more source

Guiding the Clinical Nurse Specialist role in oncology within Princess Margaret Cancer Centre. [PDF]

open access: yesCan Oncol Nurs J, 2022
Cheung V   +5 more
europepmc   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

open access: yesAdvanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu   +10 more
wiley   +1 more source

Nurse prescribing in specialist palliative care: discussion paper [PDF]

open access: yes, 2014
A working group has been established to review the current level of prescribing by registered nurse prescribers (RNP) in specialist palliative care servcies and to explore the potential and possible barriers that may exist to full ...
Office of Nursing and Midwifery Service Director, Health Service Executive (HSE)   +1 more
core  

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

open access: yesAdvanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai   +4 more
wiley   +1 more source

The Clinical Nurse Specialist in New Zealand: How Is the Role Defined? [PDF]

open access: yes, 2011
New Zealand, like many countries, is developing new advanced nursing practice roles to meet emerging needs. While much has been written about the Nurse Practitioner (NP), the role of Clinical Nurse Specialist (CNS) remains relatively unexplored and lacks
Jennifer Roberts   +2 more
core  

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

open access: yesAdvanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang   +16 more
wiley   +1 more source

Research progress of clinical nurse specialist

open access: yesHuli yanjiu, 2005
it introduced research progress of clinical nurse specialists. It expatiated mainly the phylogeny, the role function, the assessment on the value of roles, qualification of certification, problems existed in practice and the status quo of clinical nurse ...
符丽燕, 朱念琼, 康丹
doaj  

Acute and specialist health services more than a hospital, a strategic plan 1998-2006, final report

open access: yes, 1998
The purpose of this report is to articulate an appropriate mix of services for Acute and Specialist Health Care in the Northern Territory. It represents the outcome from consultation with over 500 interested stakeholders throughout the Northern Territory
Acute and Specialist Care Branch
core  

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