Results 51 to 60 of about 99,253 (306)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Divisional review of the nurse specialist role

open access: yes, 2019
Nurse specialists have been described as providing an optimal return on investment for income generation, patient safety, cost savings, and improvements in patient care and experience.
Purser, Scott   +3 more
core   +1 more source

Immunization Coverage in Young People Experiencing Homelessness and the Impact of a Nurse-led Program

open access: yesJournal of Primary Care & Community Health, 2023
Objectives: To identify the proportion of young people experiencing homelessness who are immunized against vaccine-preventable diseases, and to evaluate the impact of a nurse-led immunization program to improve vaccination coverage in this population ...
Belinda L. Tominc   +5 more
doaj   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Construction of training program for cardiac rehabilitation specialist nurse

open access: yesHuli yanjiu, 2023
ObjectiveTo construct the training program for cardiac rehabilitation specialist nurse,so as to provide reference basis for the training of cardiac rehabilitation specialist nurses in China.MethodsThrough literature review and semi-structured interview ...
LIU Shuo   +3 more
doaj  

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

A Study on the Qualifications and Ways of Selecting Candidates of Clinical Nurse Specialist in China

open access: yesHuli yanjiu, 2003
Objective: to understand the viewpoints of nursing staffs towards the essential qualifications and ways of selecting candidates of clinical nurse specialists in our country, and to provide a basis for the establishment of an eligible criteria for ...
王欣, 王惠珍
doaj  

Specializations in nursing: the students' perspective

open access: yesObzornik zdravstvene nege, 2015
Introduction: In Slovenia, nursing students and professionals do not yet have the possibility for specialized career development. The aim of the study is to determine the students' plans for their career development and their views on nursing ...
Martin Sever, Branko Bregar
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

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