Results 281 to 290 of about 608,991 (362)

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello   +10 more
wiley   +1 more source

Cryo‐EM Structures Reveal the Molecular Basis of Asymmetric Allosteric Activation by MMOB in the Hydroxylase of Soluble Methane Monooxygenase

open access: yesAdvanced Science, EarlyView.
Cryo‐EM analysis reveals an asymmetric MMOH–MMOB complex with distinct protomers, where MMOB binding triggers structural rearrangements from the surface to the active site. This conformational asymmetry shortens the Fe···Fe distance to 2.7 Å in one protomer, forming a geometry suitable for O2 activation and supporting a sequential catalytic mechanism ...
Yunha Hwang   +9 more
wiley   +1 more source

Development of Benchmark Curves to Early Detect Health-Related Productivity Deviations Using Production Indicators in Swine Nursery and Finishing Lots. [PDF]

open access: yesTransbound Emerg Dis
Pedro Mil-Homens M   +12 more
europepmc   +1 more source

An Elastocaloric Polymer with Ultra‐High Solid‐State Cooling via Defect Engineering

open access: yesAdvanced Science, EarlyView.
This work reports a defect‐engineering strategy that enables a record‐high adiabatic temperature change of up to 8.14 ± 1.76 °C in elastomers at an elevated temperature above 65 °C. Combined experimental and theoretical efforts reveal that increasing dangling‐chain defects nonmonotonically impacts the elastocaloric cooling performance of polymers due ...
Zhaohan Yu   +11 more
wiley   +1 more source

Scalable Photoactive NO2‐Sensing Framework for Plant Health Monitoring

open access: yesAdvanced Science, EarlyView.
A highly sensitive and selective NO2 gas sensor operates at room temperature using only ambient light, eliminating the need for external heating. Based on a scalable, 3D TiO2 nanoarchitecture, the device is integrated into a wireless platform and deployed on a plant. It successfully demonstrates real‐time monitoring of gas‐induced physiological stress,
Yun‐Haeng Cho   +21 more
wiley   +1 more source

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