Results 151 to 160 of about 1,952,496 (340)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Burnout and Resilience Among Nurses Practicing in High-Intensity Settings.

American Journal of Critical Care, 2015
BACKGROUND The high level of stress experienced by nurses leads to moral distress, burnout, and a host of detrimental effects. OBJECTIVES To support creation of healthy work environments and to design a 2-phase project to enhance nurses' resilience ...
C. Rushton, J. Batcheller, Kaia Schroeder, P. Donohue   +3 more
semanticscholar   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Educational levels of hospital nurses and surgical patient mortality.

Journal of the American Medical Association (JAMA), 2003
CONTEXT Growing evidence suggests that nurse staffing affects the quality of care in hospitals, but little is known about whether the educational composition of registered nurses (RNs) in hospitals is related to patient outcomes.
Linda H. Aiken, Sean P. Clarke, Robyn B. Cheung, D. Sloane, Jeffrey H Silber   +4 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Prevalence of Burnout Syndrome in Emergency Nurses: A Meta‐Analysis

Critical Care Nurse, 2017
Objective To determine the prevalence of burnout (based on the Maslach Burnout Inventory on the 3 dimensions of high Emotional Exhaustion, high Depersonalization, and low Personal Accomplishment) among emergency nurses.
J. Gómez-Urquiza, E. I. de la Fuente-Solana, Luis Albendín-García, Cristina Vargas‐Pecino, E. Ortega-Campos, G. A. Cañadas-De la Fuente   +5 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Correlation between Thinking Styles with Clinical Decision Making among Nurses Working in Educational Hospitals Affiliated to Tabriz University of Medical Sciences

Preventive Care in Nursing and Midwifery Journal, 2014
Background and Objectives: Considering the importance of thinking styles in individualschr('39') decision making, this study was conducted to investigate the correlation between thinking styles with clinical decision making among nurses working in ...
Elmira Hassanpour, Nadereh Naderi ravesh, Zahra Safavi Bayat, Malihe Nasiri, Kianoush Niroumand Zandi   +4 more
doaj  

Facilitating the development of emergency nursing in Africa: Operational challenges and successes

African Journal of Emergency Medicine, 2021
The World Health Assembly declared 2020 as the ‘Year of the Nurse and the Midwife’ in recognition of the critical contribution of both professions to global health.
Petra Brysiewicz, Tricia Scott, Emmanuel Acheampong, Ivy Muya   +3 more
doaj  

Training need assessment of nursing personnel as super specialty tertiary care hospitals in Northern India [PDF]

, 2015
Background - Super specialty tertiary care hospital equips nurses with the requisite knowledge and skills to deliver high quality care in their practice areas. This has necessitated adopting a structured approach to the training needs assessment (TNA) to
Arya, Sanjay, Gupta, Shakti Kumar, Sheweta, Kumari, Singh, Sheetal, Williamson, Swapna Naskar   +4 more
core   +1 more source