Results 61 to 70 of about 1,493,266 (349)

SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1‐Mediated Transactivation of CD47

Advanced Science, EarlyView.
Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu, Xiumei Zhao, Maolin Zang, Huiyang Yuan, Xin Qin, Xiaofeng Li, Shuo Zhao, Ruirong Tan, Keqiang Yan, Li Liu, Yidong Fan, Ning Zhang, Benkang Shi, Bo Han, Shouzhen Chen   +14 more
wiley   +1 more source

Ethical challenges in nursing studies: A scoping review [PDF]

Journal of Nursing Advances in Clinical Sciences
This scoping review aims to investigate ethical challenges in nursing studies. This review study used Farsi and English keywords, including ethics, research, challenges, obstacles to ethics, moral sensitivity, and moral distress.
Fatemeh Karjalian, Maryam Heydarzadeh, Fereshteh Davoodi   +2 more
doaj   +1 more source

Knowledge, Attitude and Practice of Nursing Ethics and Law among Nurses at Federal Medical Centre, Bida

, 2015
It is universally acknowledged that nursing profession is guided by both ethic and legal principles as it is the tools for professional discipline which gives the nurse a broad idea of what is expected of her as she moves from the protective ambiance of ...
D. Aliyu, I. T. Adeleke, S. O. Omoniyi, Balarabe Ayuba Samaila, A. Adamu, A. Abubakar   +5 more
semanticscholar   +1 more source

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

Advanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang, Wei Zhou, Marcelo Cypel, Todd L. Demmy, Gal Shafirstein, Guillermo Garza, Emily Gawrys, Joanna Bogusiewicz, Barbara Bojko, Janusz Pawliszyn   +9 more
wiley   +1 more source

Investigating the Quality of Caring Behaviors of Nurses and Patient Satisfaction in Shahid Beheshti Hospital of Yasuj

Journal of Research Development in Nursing and Midwifery, 2016
Background: Caring is the core of Nursing and holistic high-quality care is considered as one of the main concerns of nursing managers. Evaluation by main care recipients and assessment of their satisfaction with different levels of care is a way to ...
Soheila Zabolypour, Kourosh Dastan, Saeed Ghorbani, Amir Anbari, Sepideh Mohammadi   +4 more
doaj   +2 more sources

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

Does education increase ethical sensitivity a semi-experimental study

Scientific Reports
Ethics education plays a crucial role in enhancing the ethical sensitivity of nursing students. This study aimed to assess the impact of an ethics course on the ethical sensitivity levels of nursing students.
Şerife Yılmaz, Gamze Özbek Güven
doaj   +1 more source

Efficient Somatic Cell Nuclear Transfer by Overcoming Both Pre‐ and Post‐Implantation Epigenetic Barriers

Advanced Science, EarlyView.
Mammalian cloning via SCNT is limited by several epigenetic barriers. Kdm4d/Kdm5b overexpression plus TSA treatment overcomes epigenetic barriers during pre‐implantation development, while tetraploid complementation replaces defective extraembryonic lineages to bypass H3K27me3 imprinting loss to overcome epigenetic barriers in post‐implantation ...
Yamei Li, Shiyu Sun, Yuting Xu, Jixiang Zhang, Yi Du, Yaxin Cao, Zhaodi Liao, Yali Xie, Xinyan Bian, Jiantao Huang, Meijiao Wang, Zhen Liu, Qiang Sun, Falong Lu   +13 more
wiley   +1 more source

INTERNALISASI PRINSIP ETIKA PROFESI KE DALAM NORMA HUKUM POSITIF SEBAGAI UPAYA PENGEMBANGAN FIGUR HUKUM KEPERAWATAN

Jurnal Litigasi, 2019
  The code of ethics is a moral rule for people with professions that serve as a code of conduct (guidelines) in applying science and knowledge to the community. The code of ethics is not a legal norm.
Arrie Budhiartie, Joni Emirzon, Muhammad Syaifuddin   +2 more
doaj   +1 more source