Results 271 to 280 of about 5,062,228 (373)

Safety, Pharmacokinetics, and Pharmacodynamics of Osivelotor for Sickle Cell Disease: First‐in‐Human Studies in Healthy Participants and Patients

Clinical Pharmacology &Therapeutics, EarlyView.
The investigational agent osivelotor, a small molecule hemoglobin (Hb) modifier in development for the treatment of sickle cell disease (SCD), acts by increasing Hb‐oxygen affinity and inhibiting the polymerization of sickle Hb. We report safety, pharmacokinetic (PK), and pharmacodynamic (PD) data from the first two phase 1 clinical trials of ...
Eleanor A. Lisbon, R. Clark Brown, Andrew Redfern, Ken Duchin, Aline Barth, Erika S. Roberts, Polo Gaputan, Kobina Dufu, Arthur Lo, Mira Patel Pochron, David R. Archer, Wai Chin, Karena Kong, Carla B. Washington, Adeyemi Adenola, Eric I. Zimmerman   +15 more
wiley   +1 more source

Bidirectional Interaction Between Liposomal Amphotericin B Pharmacokinetics and Parasite Dynamics in Patients With Post‐Kala‐Azar Dermal Leishmaniasis: Potential Implications for Optimal Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Post‐kala‐azar dermal leishmaniasis (PKDL) involves a high macrophage burden in which the Leishmania parasites reside. Liposomal amphotericin B (LAmB) plays a key role in the treatment of PKDL. The mononuclear phagocyte system (MPS) is crucial in the distribution of liposomal drugs as well as the leishmaniasis pathophysiology.
Wan‐Yu Chu, Om Prakash Singh, Shyam Sundar, Dinesh Mondal, Krishna Pandey, Pradeep Das, Ignace C. Roseboom, Sheeraz Raja, Ana Torres, Eugenia Carrillo, Alwin D.R. Huitema, Fabiana Alves, Thomas P.C. Dorlo   +12 more
wiley   +1 more source

A Cross-Sectional Study of How Cancer Nurses Document the Nursing Processes Using Digital Health Record (DHR)

Delilah Shelley, Phillip S. Kavanagh, Deborah Davis, Catherine Paterson, Rebecca Heland   +4 more
openalex   +1 more source

Effectiveness of Remote Family Education and Support Program for Parents of Adolescents With Eating Disorders Based on Interpersonal Psychotherapy: A Randomized Controlled Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Given the frequent conflict between parents and adolescents with eating disorders, we aimed to develop a remote family education and support program (rFESP) for parents based on the principles of interpersonal psychotherapy (IPT) and investigate its effect on promoting effective communication at home.
Fujika Katsuki, Hanayo Sawada, Yuka Kawasaki, Masaki Kondo, Atsurou Yamada, Norio Watanabe   +5 more
wiley   +1 more source

Commentary: beyond staffing: what drives patient satisfaction in nursing? [PDF]

J Res Nurs
Ramdani WF.
europepmc   +1 more source

Identification and Management of Binge‐Eating Disorder and Bulimia Nervosa in Primary Care Settings: A Qualitative Systematic Review of Healthcare Professionals' and Patients' Perceptions

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To understand how the identification and management of binge‐eating disorder (BED) and bulimia nervosa (BN) in primary care settings are perceived by both patients and healthcare professionals, and how rates of identification and referral for support may be improved.
Stella Kozmér, Christopher O'Rouke, Natalia S. Lawrence, Jane R. Smith, Samantha B. van Beurden   +4 more
wiley   +1 more source

The impact of the February 6, 2023, earthquake in Türkiye on the nursing workforce: brain drain and strategic solutions for sustainability in the healthcare sector. [PDF]

BMC Nurs
Kara B, Yüksel S, Renkli AS.
europepmc   +1 more source

Evaluation of the Nursing Process record in a University Hospital in Pernambuco: a cross-sectional study

Viviane Tannuri Ferreira Lima Falcão, Bruna Santos Mota, Laura Morais Inojosa da Silva, Izabel Barros de Arruda   +3 more
openalex   +1 more source

Weight Trajectories During Inpatient Treatment for Anorexia Nervosa: A Dynamic Time Warp Analysis

International Journal of Eating Disorders, EarlyView.
ABSTRACT Background Restoring weight is a primary goal during anorexia nervosa (AN) treatment. Previous studies linked different weight gain profiles to treatment outcomes, but there is currently no consensus on profile shapes and numbers. We argue that heterogeneity stems from temporal distortions (“warping”) in weight gain, and that similar weight ...
Marianne Tokic, Georg Halbeisen, Karsten Braks, Thomas J. Huber, Nina Timmesfeld, Georgios Paslakis   +5 more
wiley   +1 more source