Results 31 to 40 of about 157,111 (264)

Correlation Between Fecal Microbiota and Corticosteroid Responsiveness in Primary Immune Thrombocytopenia: an Exploratory Study

Advanced Science, EarlyView.
This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu, Zhuo‐Yu An, Li‐Juan Cui, Meng‐Yu Xiao, Ye‐Jun Wu, Wei Li, Bang‐Shuo Zhang, Li Yu, Jia Feng, Zhuo‐Gang Liu, Ru Feng, Zhong‐Xing Jiang, Rui‐Bin Huang, Hong‐Mei Jing, Jin‐Hai Ren, Xiao‐Yu Zhu, Yun‐Feng Cheng, Yu‐Hua Li, He‐Bing Zhou, Da Gao, Yi Liu, Fan Yu, Xin Wang, Jian‐Lin Qiao, Dai‐Hong Hu, Lu‐Lu Wang, Meng‐Tong Zang, Qi Chen, Qing‐Yuan Qu, Jian‐Ying Zhou, Meng‐Lin Li, Yu‐Xiu Chen, Qiu‐Sha Huang, Hai‐Xia Fu, Yue‐Ying Li, Qian‐Fei Wang, Xiao‐Jun Huang, Xiao‐hui Zhang, the Cooperative ITP Working Group   +38 more
wiley   +1 more source

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

Advanced Science, EarlyView.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu   +13 more
wiley   +1 more source

Exercise without Weight Loss Prevents Seasonal Decline in Vitamin D Metabolites: The VitaDEx Randomized Controlled Trial

Advanced Science, EarlyView.
In people with overweight or obesity, regular exercise even without weight loss or vitamin D supplementation completely prevents the usual winter decline in the vitamin D metabolite that maintains health at a cellular level, 1,25(OH)2D3, and ameliorates the decline in the vitamin D status marker 25(OH)D.
Oliver J. Perkin, Sophie E. Davies, Martin Hewison, Kerry S. Jones, Javier T. Gonzalez, James A. Betts, Carl Jenkinson, Mark A. Lindsay, Sarah R. Meadows, Damon A. Parkington, Albert Koulman, Dylan Thompson   +11 more
wiley   +1 more source

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Advanced Science, EarlyView.
This study develops TMEclassifier, a machine‐learning tool that classifies cancers into three distinct subtypes—Immune exclusive (IE), immune suppressive (IS), and immune activated (IA)—which exhibit significant heterogeneity and necessitate customized therapeutic strategies.
Dongqiang Zeng, Yunfang Yu, Wenjun Qiu, Qiyun Ou, Qianqian Mao, Luyang Jiang, Jianhua Wu, Jiani Wu, Huiyan Luo, Peng Luo, Wenchao Gu, Na Huang, Siting Zheng, Shaowei Li, Yonghong Lai, Xiatong Huang, Yiran Fang, Qiongzhi Zhao, Rui Zhou, Huiying Sun, Wei Zhang, Jianping Bin, Yulin Liao, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Min Shi, Wangjun Liao   +27 more
wiley   +1 more source

Accurate and Noninvasive Dysphagia Assessment via a Soft High‐Density sEMG Electrode Array Conformal to the Submental and Infrahyoid Muscles

Advanced Science, EarlyView.
A stretchable, breathable, large‐area high‐density sEMG (HD‐sEMG) electrode array is reported, which enables seamless integration to the complex surface of the submental and infrahyoid muscles to detect high‐fidelity HD‐sEMG signals during swallowing.
Weijie Hong, Lin Mao, Kai Lin, Chongyuan Huang, Yanyan Su, Shun Zhang, Chengjun Wang, Daming Wang, Jizhou Song, Zuobing Chen   +9 more
wiley   +1 more source

Incorporating economic multipliers in a bid adjustment algorithm for public food procurement decision making

Applied Economic Perspectives and Policy, EarlyView.
Abstract We present an adjusted bid price mechanism that incorporates economic multiplier effects in public food procurement decision making. Under Input–Output model assumptions, the algorithm estimates enhanced tax revenues to state governments through multiplier effects associated with in‐state supplier purchasing.
Todd M. Schmit, Xiaoyan Liu
wiley   +1 more source

Labor shortages and farmer adaptation strategies

Applied Economic Perspectives and Policy, EarlyView.
Abstract Labor shortages are a growing challenge for U.S. agricultural producers, but little is known about farmers' adaptation strategies. We estimate the statistical relationship between farm labor shortages and adaptation strategies among California farmers.
Myat Thida Win, Zachariah Rutledge, Mywish K. Maredia   +2 more
wiley   +1 more source

Chinese Expert Consensus on Standardized Outpatient Management of Sarcopenia in the Elderly (2024)

AGING MEDICINE, EarlyView.
In China, specific sarcopenia clinics are not sufficient for outpatients. This consensus combines the professional advice of domestic geriatrics experts, summarizes the existing domestic experience in the establishment of sarcopenia clinics, and provides guidance for the management of sarcopenia clinics.
Zhang Qin, Kang Lin, Wang Jianye, Xi Huan, Yu Pulin, Zhang Cuntai, Hidenori Arai, Tuo Xiping, Yang Yunmei, Liu Xiaohong, Chen Chan, Chen Huaihong, Chen Xujiao, Cheng Lijuan, Deng Linzi, Ding Yi, Dong Birong, Dong Juan, Gao Yue, Gu Haifeng, Guo Yan, Han Hui, Hidenori Arai, Hu Fang, Shangcheng District, Hu Jian, Hu Yao‐min, Hu Yixin, Huang Gairong, Jian Zaijin, Jiang Wenjing, Kang Lin, Li Fuchao, Li Jian, Li Jing, Li Tianlang, Lin Fan, Liu Juan, Liu Xiaohong, Liu Xuejun, Lou Huiling, Luo Lan, Luo Man, Ma Lina, Mao Yongjun, Nie Jing, Ouyang Xiaojun, Qi Guoxian, Qiao Wei, Shi Hong, Tian Tao, Tuo Xiping, Wang Chaohui, Wang Jiaqiu, Wang Jianye, Wang Peng, Wang Quan, Wang Xiaonan, Wang Yuan, Wang Zhaodi, Wei Yanan, Wu Jun, Wu Shuhua, Wu Xiaohe, Xi Huan, Xin Xiaofeng, Xu Meiqun, Yang Yunmei, Yin Shi, Yu Plin, Zhang Cuntai, Zhang Qin, Zhang Xiaoyan, Zhang Ying, Zhao Xiaohong, Zhong Yuan, Zhou Baiyu, Zhou Houguang, Zhou Xiaohui   +78 more
wiley   +1 more source

Measuring specialty crop grower willingness to pay for genetic modification and genetic editing

Agribusiness, EarlyView.
Abstract In contrast to the widespread adoption of agricultural commodities modified using biotechnology, the adoption rate of bioengineered specialty crops by growers remains low. The use of bioengineered crops has been controversial since their introduction in the 1990s due to concerns about their potentially harmful effects to human health, the ...
Marie Abbey, Alan G. Smith, Chengyan Yue, Corissa Marson, Yufeng Lai, Carrie Stowers   +5 more
wiley   +1 more source

Bowel preparation and surgical site infections in laparoscopic and robot‐assisted right‐sided colon cancer surgery with intracorporeal anastomosis: A retrospective study

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study investigated risk factors for surgical site infections (SSIs) in right‐sided colon cancer surgeries using intracorporeal anastomosis (IA). The results demonstrated that preoperative oral antibiotics (OA) significantly reduced SSI rates, with OA identified as an independent protective factor, suggesting its beneficial role in ...
Naoya Ozawa, Tomohiro Yamaguchi, Takumi Kozu, Tatsuki Noguchi, Takashi Sakamoto, Shimpei Matsui, Toshiki Mukai, Takashi Akiyoshi, Yosuke Fukunaga   +8 more
wiley   +1 more source