Results 51 to 60 of about 812,172 (264)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Impact of methionine nutrition on the leaf proteome of Lupinus angustifolius L. and Vicia faba L. [PDF]

open access: yes, 2011
Grain legumes possess a gernerally favourable seed protein amino acid composition but low contents of sulfur amino acids decrease their nutrient value. To enhance the methionie content of local grain legumes by plant breeding, phenotypical attributes for
Gau, Achim Ernst   +3 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Short-term Effects of Nutrients on a Barrier Island Grassland Community [PDF]

open access: yes, 2017
Increased nutrient availability globally has the potential to affect community functional composition of plants in nutrient limited environments, such as coastal grassland systems.
Moulton, Ashley
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Potential for improvement of population diet through reformulation of commonly eaten foods [PDF]

open access: yes
Food reformulation: Reformulation of foods is considered one of the key options to achieve population nutrient goals. The compositions of many foods are modified to assist the consumer bring his or her daily diet more in line with dietary recommendations.
Hendriksen, M.   +2 more
core   +2 more sources

Links between soil microbial communities and plant traits in a species-rich grassland under long-term climate change [PDF]

open access: yes, 2017
Climate change can influence soil microorganisms directly by altering their growth and activity but also indirectly via effects on the vegetation, which modifies the availability of resources.
Askew, Andrew P.   +5 more
core   +3 more sources

Multiple environmental controls explain global patterns in soil animal communities [PDF]

open access: yes, 2020
Soil animals play important roles in ecosystem functioning and stability, but the environmental controls on their communities are not fully understood. In this study, we compiled a dataset of soil animal communities for which the abundance and body mass ...
Johnston, Alice S. A., Sibly, Richard M.
core   +1 more source

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