Results 131 to 140 of about 253,788 (309)
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Extensive regulation of metabolism and growth during the cell division cycle
, 2013 Yeast cells grown in culture can spontaneously synchronize their respiration, metabolism, gene expression and cell division. Such metabolic oscillations in synchronized cultures reflect single-cell oscillations, but the relationship between the ...
Botstein, David +2 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
The economic value of nutrient cycling in the Swartkops and Sundays River estuaries
South African Journal of ScienceNutrient cycling, a fundamental ecological process, directly impacts the health and functionality of marine environments and plays a pivotal role in maintaining water quality and supporting diverse marine life and human health.
Rozanne Peacock +3 more
doaj +1 more source
Greenhouse gas budgets of crop production : current and likely future trends [PDF]
, 2010 Publisher ...
Flynn, Helen C, Smith, Pete
core
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Nutrient budgets on organic farms: a review of published [PDF]
, 2002 This report was presented at the UK Organic Research 2002 Conference. On organic farms it is important that a balance between inputs and outputs of nutrients is achieved.
Stockdale, Elizabeth A +1 more
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Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie +3 more
wiley +1 more source
Modeling energy flow and nutrient cycling in natural semiarid grassland ecosystems with the aid of thematic mapper data [PDF]
Energy flow and nutrient cycling were modeled as affected by herbivory on selected intensive sites along gradients of precipitation and soils, validating the model output by monitoring selected parameters with data derived from the Thematic Mapper (TM ...
Lewis, James K.
core +1 more source