Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Application of PSO-BPNN-PID Controller in Nutrient Solution EC Precise Control System: Applied Research. [PDF]
Sensors (Basel), 2022 Wang Y, Liu J, Li R, Suo X, Lu E.
europepmc +1 more source
Effect of Electrical Conductivity of Nutrient Solution and Light Spectra on the Main Phytochemical Content of <i>Sonchus tenerrimus</i> L. Under Wild and Controlled Environments. [PDF]
Plants (Basel)Cunha-Chiamolera TPL +4 more
europepmc +1 more source
Production and Physiological Quality of Seeds of Mini Watermelon Grown in Substrates with a Saline Nutrient Solution Prepared with Reject Brine. [PDF]
Plants (Basel), 2022 Alves TRC +15 more
europepmc +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Integrated Analysis of Transcriptome and Metabolome Reveals the Accumulation of Anthocyanins in Black Soybean (<i>Glycine max</i> L.) Seed Coats Induced by Low Nitrogen Concentration in the Nutrient Solution. [PDF]
Plants (Basel)Liang S +5 more
europepmc +1 more source
Growth and Nutrient Utilization in Basil Plant as Affected by Applied Nutrient Quantity in Nutrient Solution and Light Spectrum. [PDF]
Biology (Basel), 2022 Ren X +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley +1 more source