Results 121 to 130 of about 5,431,365 (396)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Most Australians do not meet recommendations for dairy consumption: findings of a new technique to analyse nutrition surveys

Australian and New Zealand Journal of Public Health, 2012
Objective: To describe the pattern of dairy consumption in Australians aged 12 years and over, and assess the extent to which the population meets national recommendations.
James C. Doidge, Leonie Segal
doaj   +1 more source

Nutrient profile labelling: consumers’ perceptions in Germany and Belgium [PDF]

Growing consumer interest in food and health has motivated the European food industry to provide more simple information on the nutritional composition of foods. In addition to the traditional back-of-pack nutrition table, simplified front-of-pack labels
Hoefkens, Christine, Moeser, Anke, Van Camp, John, Verbeke, Wim   +3 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Consumption of Pork Products: Now and to the Year 2020 [PDF]

Data from the recent USDA's food consumption surveys are used to describe pork consumption patterns, to estimate a censored demand system for pork cuts, and to forecast pork consumption.
Davis, Christopher G., Lin, Biing-Hwan, Yen, Steven T.   +2 more
core   +1 more source

Incorporating Nutrition Education Classes into Food Pantry Settings: Lessons Learned in Design and Implementation [PDF]

, 2015
The project reported here evaluated the effectiveness of nutrition education at food pantries. We offer best practices for future Extension-based nutrition programming with this clientele.
Bloom, J Dara, Bowen, Sarah, Hardison-Moody, Annie, Jones, Lorelei, Leach, Brandi, Sheldon, Marissa   +5 more
core   +2 more sources

Reduction in human papillomavirus (HPV) prevalence among young women following HPV vaccine introduction in the United States, National Health and Nutrition Examination Surveys, 2003-2010.

Journal of Infectious Diseases, 2013
BACKGROUND Human papillomavirus (HPV) vaccination was introduced into the routine immunization schedule in the United States in late 2006 for females aged 11 or 12 years, with catch-up vaccination recommended for those aged 13-26 years.
L. Markowitz, S. Hariri, Carol Lin, Eileen F. Dunne, M. Steinau, G. Mcquillan, E. Unger   +6 more
semanticscholar   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Bayesian Hierarchical Spatial Regression Models for Spatial Data in the Presence of Missing Covariates with Applications [PDF]

arXiv, 2020
In many applications, survey data are collected from different survey centers in different regions. It happens that in some circumstances, response variables are completely observed while the covariates have missing values. In this paper, we propose a joint spatial regression model for the response variable and missing covariates via a sequence of one ...
arxiv