Results 31 to 40 of about 181,884 (258)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Vitamin A and iron supplementation of Indonesian pregnant women benefits vitamin A status of their infants

, 2001
Many Indonesian infants have an inadequate nutritional status, which may be due in part to inadequate maternal nutrition during pregnancy. This study was designed to investigate whether infant nutritional status could be improved by maternal vitamin A ...
Muslimatun, S., West, C.E., Schultink, W., Schmidt, M.K., Hautvast, J.G.A.J.   +4 more
core   +1 more source

Iron status and Helicobacter pylori infection in symptomatic children: an international multi-centered study [PDF]

, 2013
Objective:Iron deficiency (ID) and iron deficiency anaemia (IDA) are global major public health problems, particularly in developing countries. Whilst an association between H.
Sanderson Ian R., Harris, PR, Dermot Kelleher (215498), Ian R. Sanderson (430956), Ian R Sanderson, Henry J Windle, Harris, Paul, Jean E Crabtree, Bittencourt Paulo Fernando Souto, Walker, Marjorie M., Queiroz, DMM, Lucia Porto Fonseca de Castro (430959), Rocha, GA, Andrea Villagrán, Magalhaes Queiroz, DM, Kelleher, Dermot, Dulciene Maria Magalhaes Queiroz (381990), Harris Paul R., Paul R. Harris (430955), Lucia Porto Fonseca de Castro, Rocha Andreia Maria Camargos, Andrea Villagrán (430960), Carvalho, Simone Diniz, Villagran, Andrea, Serrano Carolina, Gifone Aguiar Rocha (381993), Walker Marjorie M., Carvalho Simone Diniz, Windle, HJ, Rocha, AMC, Crabtree Jean E., Dermot Kelleher, Paulo Fernando Souto Bittencourt (381996), de Castro, LPF, Dulciene Maria Magalhaes Queiroz, Kelleher Dermot, Walker, MM, Marjorie M. Walker (430958), Serrano, C, Magalhaes Queiroz, Dulciene Maria, Sanderson, IR, de Castro Lucia Porto Fonseca, Carolina Serrano, Rocha Gifone Aguiar, Fonseca de Castro, Lucia Porto, Andreia Maria Camargos Rocha (381991), Bittencourt, PFS, Crabtree, JE, Souto Bittencourt, PF, Simone Diniz Carvalho (381995), Simone Diniz Carvalho, Villagrán, A, Rocha, Gifone Aguiar, Henry J. Windle (430957), Windle, Henry J., Serrano, Carolina, Jean E. Crabtree (298225), Villagrán Andrea, Crabtree, Jean E., Andreia Maria Camargos Rocha, Paul R Harris, Paulo Fernando Souto Bittencourt, Kelleher, D, Souto Bittencourt, Paulo Fernando, Gifone Aguiar Rocha, Windle Henry J., Camargos Rocha, Andreia Maria, Fonseca de Castro, LP, Marjorie M Walker, Carvalho, SD, Carolina Serrano (430961), Queiroz Dulciene Maria Magalhaes, Sanderson, Ian R., Camargos Rocha, AM   +73 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Nutritional Status of Adolescent Girls from Rural Communities of Tigray, Northern Ethiopia

, 2009
Background: Addressing the nutritional needs of adolescents could be an important step towards breaking the vicious cycle of intergenerational malnutrition. Objective: Assess nutritional status of rural adolescent girls. Design: Cross-sectional. Methods:
Linderhof, V.G.M., Zenebe, A., Girmay, G., Stroecker, B., Hagos, F., Kruseman, G., Mekonen, Y., Mulugeta, A.   +7 more
core   +1 more source

Effectiveness of the National Program of Complementary Feeding for older adults in Chile on vitamin B12 status in older adults; secondary outcome analysis from the CENEX Study (ISRCTN48153354). [PDF]

, 2013
BACKGROUND: Older people are at increased risk of vitamin B12 deficiency and the provision of fortified foods may be an effective way to ensure good vitamin B12 status in later life.
Sánchez Reyes, Hugo, Albala Brevis, Cecilia, Uauy, Ricardo, Alan D Dangour, Cecilia Albala, Lera, Lydia, Hugo Sanchez, Sanchez, Hugo, Lydia Lera, Uauy Dagach-Imbarack, Ricardo, Dangour, Alan D., Lera Marques, Lydia, Dangour, Alan D, Ricardo Uauy, Hugo HugoSanchez, Albala, Cecilia   +15 more
core   +1 more source

Proposal to Screen for Zinc and Selenium in Patients with IgA Deficiency

, 2023
The increase in life expectancy can be a consequence of the world’s socioeconomic, sanitary and nutritional conditions. Some studies have demonstrated that individuals with a satisfactory diet variety score present a lower risk of malnutrition and ...
Abu Jamra, Soraya Regina, Fernando Barbosa, Anderson Marliere Navarro, Komatsu, Camila Gomes [UNESP], Roxo-Junior, Persio, Navarro, Anderson Marliere, Persio Roxo-Junior, Soraya Regina Abu Jamra, Camila Gomes Komatsu, Barbosa, Fernando   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source