Results 71 to 80 of about 143,581 (309)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Interactions and potential implications of Plasmodium falciparum-hookworm coinfection in different age groups in south-central Côte d'Ivoire [PDF]

, 2012
BACKGROUND: Given the widespread distribution of Plasmodium and helminth infections, and similarities of ecological requirements for disease transmission, coinfection is a common phenomenon in sub-Saharan Africa and elsewhere in the tropics. Interactions
Richard F Hurrell, Aurélie A Righetti, N'Goran Eliézer K., Righetti, Aurélie A., N'Goran, E. K., Ahou-Yah G Koua, Utzinger, Jürg, Glinz, D., Koua Ahou-Yah G., Hurrell Richard F., Wegmüller, Rita, Rita Wegmüller, Utzinger Jürg, Dominik Glinz, Righetti Aurélie A., Adiossan Lukas G., Jürg Utzinger, Niamké, S., Adiossan, L. G., Lukas G Adiossan, Righetti, A. A., Utzinger, J., Koua, Ahou-Yah G., Niamké Sébastien, Adiossan, Lukas G., Niamké, Sébastien, Koua, A. Y. G., Hurrell, R. F., Glinz Dominik, Glinz, Dominik, Wegmüller Rita, Eliézer K N'Goran, N'Goran, Eliézer K., Sébastien Niamké, Hurrell, Richard F., Wegmüller, R.   +35 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Why do adult women in Vietnam take iron tablets? [PDF]

, 2006
Background: Conducting iron supplementation programs has been a major strategy to reduce iron deficiency anemia in pregnancy. However, only a few countries have reported improvements in the anemia rate at a national level. The strategies used for control
Binns, C.W., Jimba Masamine, Binns Colin W, Jimba, M., Aikawa, R., Nguen, K.C., Nguen Khan C, Zhao Yun, Aikawa Ritsuko, Lee, M.K., Lee Mi Kyung, Zhao, Y.   +11 more
core   +2 more sources

Azolla pinnata mitigates pendimethalin induced immunotoxicity, oxidative stress and histopathological changes in Oreochromis niloticus

Scientific Reports
Aquatic animals face multiple threats, including pesticides, heavy metals, and other environmental pollutants, risking their health and survival. Limited bioremediation studies have been conducted on the detrimental impacts of herbicides on fish.
Nagwa I. S. Abu-Zahra, Mofeed Gouda, Mohamed M. Elseify, Mona E. Abass, Mohammed S. El-Gohary, Eman T. El-sokary   +5 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

The nutritional transition and diet-related chronic diseases in Asia [PDF]

The nutritional transition currently occurring in Asia is one facet of a more general demographic/nutritional/epidemiological transition that accompanies development and urbanization, marked by a shift away from relatively monotonous diets of varying ...
Horton, Susan, Kim, Soowon, Popkin, Barry M.   +2 more
core