Results 161 to 170 of about 1,018,439 (310)

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

open access: yesAdvanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li   +17 more
wiley   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

open access: yesAdvanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen   +11 more
wiley   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

open access: yesAdvanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge   +21 more
wiley   +1 more source

Controlled Nutritional Status Score and Prognostic Nutritional Index for the Prediction of Postoperative Subdural Hematoma

open access: yesInternational Journal of General Medicine
Huisong Chu,1 Shuang Sun,2 Hui Jiang,2 Ling Li,2 Yu Tian2 1Department of Neurosurgery, Affiliated Hospital of Chengde Medical University, Chengde, Hebei Province, People’s Republic of China; 2Department of Nutrition, Affiliated Hospital of Chengde ...
Chu H, Sun S, Jiang H, Li L, Tian Y
doaj  

Why we should be worried about the future of nutrition

open access: yesSocial Determinants of Health, 2023
Sushmitha Mahantshetti   +4 more
doaj   +1 more source

NUTRITIONAL STATUS AND INTESTINAL MICROBIOCENOSIS IN COMPLETE FASTING IN YOUNG VOLUNTEER

open access: hybrid, 2023
Н.В. Евдокимова   +3 more
openalex   +2 more sources

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