Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
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Optimizing nutritional support in upper gastrointestinal surgery: A comprehensive review of feeding jejunostomy techniques and outcomes. [PDF]
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The nutrition and food-related roles, experiences and support needs of female family carers of malnourished older rehabilitation patients [PDF]
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Standards for Specialized Nutrition Support for Adult Residents of Long‐Term Care Facilities [PDF]
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Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
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Impact of targeted nursing care and nutritional support on clinical outcomes in diabetic nephropathy patients undergoing maintenance hemodialysis. [PDF]
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Influence of rapid recovery nutritional support on functional recovery and hospitalization duration in patients undergoing minimally invasive lumbar surgery. [PDF]
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openalex
WP(Pip) is a mixture of whey protein and piperine‐loaded nanoemulsion stabilized by WP through microfluidic homogenization. Acting as a “smart key,” piperine opens epithelial tight junctions to enhance absorption of whey protein and, thereby increasing circulating amino acid availability, synergistically up‐regulates the mTOR signaling pathway in ...
Qing Yue +10 more
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Nutritional support contributes to improving cardiac function and nutritional status in atrial fibrillation patients receiving treatment with esmolol hydrochloride. [PDF]
Liu X, Fan Y, Liu Z.
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