Results 261 to 270 of about 10,198,424 (331)

CACLENS: A Multitask Deep Learning System for Enzyme Discovery

Advanced Science, EarlyView.
CACLENS, a multimodal and multi‐task deep learning framework integrating cross‐attention, contrastive learning, and customized gate control, enables reaction type classification, EC number prediction, and reaction feasibility assessment. CACLENS accelerates functional enzyme discovery and identifies efficient Zearalenone (ZEN)‐degrading enzymes.
Xilong Yi, Yingzhu Tan, Huikang Lin, Guoqing Zhang, Ye Tian, Aibo Wu   +5 more
wiley   +1 more source

Effects of nutritional support during neoadjuvant therapy on perioperative outcome in esophageal cancer: a real-world cohort study. [PDF]

J Thorac Dis
Yang Y, He Y, Wei W, Wu Y, Chen H, Gao Y, Yan W, Fan M, Ma S, Liang Z, Xiong H, Dai L, Chen KN.   +12 more
europepmc   +1 more source

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

Nutritional Status and Nutritional Support in Patients with Gastrointestinal Diseases. [PDF]

Nutrients
Jabłońska B.
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Development of A Novel Scoring Index to Quantify the Need for Nutritional Support Interventions During Stem Cell Transplant and Gene Therapy in Children. [PDF]

J Hum Nutr Diet
Gurumurthy G, Dixon R, Whiteley V, Horgan C, Mustafa O, Williams N, Wynn R.   +6 more
europepmc   +1 more source

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

Advanced Science, EarlyView.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin   +14 more
wiley   +1 more source

The efficacy of high-protein nutritional support on mortality, clinical outcomes, and nutritional adequacy in critically ill patients: a double‑center randomized controlled trial. [PDF]

Nutr Metab (Lond)
Badpeyma M, Sedaghat A, Moghaddam AB, Khadem-Rezaiyan M, Sistanian F, Bagherniya M, Ranjbar G, Fazeli F, Norouzy A.   +8 more
europepmc   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Economic evaluation of integrating nutritional support intervention in India's National Tuberculosis Elimination Programme: implications for low-income and middle-income countries. [PDF]

BMJ Open
Jyani G, Prinja S, Nadipally S, Shankar M, Rao N, Rao V, Singh RR, Shah A, Chugh Y, Monga D, Sharma A, Aggarwal A.   +11 more
europepmc   +1 more source