Results 221 to 230 of about 336,684 (294)

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source

Field-effect detected magnetic resonance of nitrogen-vacancy centers in diamond based on all-carbon Schottky contacts. [PDF]

Commun Eng
Le XP, Mayer L, Magaletti S, Schmidt M, Roch JF, Debuisschert T.   +5 more
europepmc   +1 more source

Wireless blood pressure sensor implantation in sheep: A detailed technique

Animal Models and Experimental Medicine, EarlyView.
Twelve adult sheep underwent wireless blood pressure sensor implantation. The procedure lasted an average of 36 min, with mean systolic and diastolic blood pressures of 93 ± 6 and 65 ± 5 mmHg, respectively. This rapid, minimally invasive protocol is a powerful platform for cardiovascular device development.
David Santer, Paul Ecker, Judith Radloff, Katharina Heissl, Smruti Mirchandani, Sabine Leitner, Bruno Mora, Martin Czerny, Roman Gottardi, Michael Moore, Bruno K. Podesser   +10 more
wiley   +1 more source

Swine influenza A replicon particle and live attenuated influenza virus vaccines induce differential systemic and mucosal antibody and T cell responses. [PDF]

Front Vet Sci
Wymore Brand M, Kaplan BS, Souza CK, Wiarda JE, Kimble JB, Arruda B, Perez DR, Baker AL.   +7 more
europepmc   +1 more source

NMR spectroscopy with single shallow NV centers

, 2019
openaire   +3 more sources

Individualized Atrophy‐Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed‐Effects Modeling

Annals of Neurology, EarlyView.
Objective Age of symptom onset is highly variable in familial frontotemporal lobar degeneration (f‐FTLD). Accurate prediction of onset would inform clinical management and trial enrollment. Prior studies indicate that individualized maps of brain atrophy can predict conversion to dementia in f‐FTLD.
Shubir Dutt, Dana Leichter, Yann Cobigo, Amy Wolf, John Kornak, Annie Clark, Lucy L. Russell, Arabella Bouzigues, David M. Cash, Martina Bocchetta, Molly Olzinski, Brian Appleby, Ece Bayram, Barbara Borroni, Andrea Bozoki, Chris R. Butler, David Clark, Rhian S. Convery, R. Ryan Darby, Alexandre de Mendonça, Bradford Dickerson, Kimiko Domoto‐Reilly, Simon Ducharme, Eve Ferry‐Bolder, Elizabeth Finger, Phoebe H. Foster, Douglas R. Galasko, Daniela Galimberti, Alexander Gerhard, Nupur Ghoshal, Caroline Graff, Neill Graff‐Radford, Ian M. Grant, Chadwick M. Hales, Lawrence S. Honig, Ging‐Yuek Hsiung, Edward D. Huey, David Irwin, Lize C. Jiskoot, Walter Kremers, Justin Y. Kwan, Robert Laforce, Isabelle Le Ber, Gabriel C. Léger, Johannes Levin, Irene Litvan, Ian R. Mackenzie, Mario Masellis, Mario F. Mendez, Fermin Moreno, Chiadi Onyike, Markus Otto, Belen Pascual, Peter Pressman, Rosa Rademakers, Eliana Marisa Ramos, Aaron Ritter, Erik D. Roberson, James B. Rowe, Raquel Sanchez‐Valle, Isabel Santana, Harro Seelaar, Allison Snyder, Sandro Sorbi, Matthis Synofzik, Maria Carmela Tartaglia, Pietro Tiraboschi, John C. van Swieten, Marijne Vandebergh, Rik Vandenberghe, Hilary W. Heuer, Bruce L. Miller, William W. Seeley, Maria Luisa Gorno‐Tempini, Joel H. Kramer, Leah Forsberg, Kejal Kantarci, Bradley F. Boeve, Adam L. Boxer, Jonathan D. Rohrer, Howard J. Rosen, Adam M. Staffaroni, FTD Prevention Initiative (FPI) investigators   +82 more
wiley   +1 more source

The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications

Angewandte Chemie, EarlyView.
This work describes the synthesis of bench‐stable dicationic carboranes. Their enhanced electrophilicity is documented by opening the clusters with weak nucleophiles or dihydrogen. The surprising stability of positively charged carboranes in water enabled a study of their in vitro antiproliferative activity, which surpassed the effects of doxorubicin ...
Vlastimil Němec, Josef Holub, Maksim A. Samsonov, Zdeňka Růžičková, Josef Cvačka, Ján Vančo, Zdeněk Trávníček, Jan Belza, Zdeněk Dvořák, Jan Vrána, Aleš Růžička   +10 more
wiley   +2 more sources

Lysyl Oxidase Reduces Neutrophil Extravasation in Response to P. aeruginosa in an Infection‐on‐a‐Chip Model

Advanced NanoBiomed Research, EarlyView.
Lysyl oxidase crosslinking of type I collagen decreases neutrophil extravasation through an endothelium during the initial response to P. aeruginosa. This decrease in extravasation is likely due to the increase in VE‐cadherin expression between endothelial cells seeded on LOX‐crosslinked collagen hydrogels.
Christopher J. Calo, Tanvi Patil, Josephine Fouts, Eric L. Ginter, Margaret Radke, Hannah K. Weppner, Justin M. Owens, Laurel E. Hind   +7 more
wiley   +1 more source

Intramolecular Charge‐Transfer Dopants Enable Isolated Triplet Excitons as Spin Qutrits in a Single Crystal

Angewandte Chemie, EarlyView.
Photoexcitation of an intramolecular charge‐transfer molecule doped into single crystals of a structurally similar host molecule results in well‐ordered, spectrally addressable, and orientation‐tunable triplet excitons that maintain coherence at elevated temperatures.
Yaoyao Han, Samuel B. Tyndall, Kathryn R. Peinkofer, Yuheng Huang, Ryan M. Young, Matthew D. Krzyaniak, Michael R. Wasielewski   +6 more
wiley   +2 more sources

Protein‐Template Gold Nanoclusters Induce Differentiation and Modify the Functional Properties of Primary Astrocytes

Advanced NanoBiomed Research, EarlyView.
The incubation of primary astrocytes with fAuNCs‐BSA induces: (A) long‐term effects including fAuNCs‐BSA internalization, red cell fluorescence, differentiation, upregulation of Ca2+ signaling, Cl‐current, and cell volume regulation. B) Short‐term (200 ms) stimulation with UV LED light increases in Ca2+ signaling and inhibition of K+ current. Astrocyte
Roberta Fabbri, Karima Jeneh Perry, Emanuela Saracino, Chiara Lazzarini, Anna Mariano, Diletta Spennato, Maria Grazia Mola, Maria Grazia Raucci, Alessandro Kovtun, Marianna Barbalinardo, Giorgia Conte, Denis Gentili, Marco Caprini, Vincenzo Palermo, Roberto Zamboni, Luigi Ambrosio, Wolfgang Losert, Andrea Candini, Grazia Paola Nicchia, Raj K. Gupta, Valentina Benfenati, Shashi P. Karna   +21 more
wiley   +1 more source