Results 51 to 60 of about 98 (73)
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Cancer Chemotherapy and Pharmacology, 2000
The pharmacokinetics of TNP-470 and its major metabolites were investigated in AIDS patients enrolled in a phase I dose escalation trial for the treatment of Kaposi's sarcoma. The patients received TNP-470 by 1-h intravenous infusion in dose cohorts of 10, 20, 30, 40, 50 and 70 mg/m2.
J D, Moore +5 more
openaire +2 more sources
The pharmacokinetics of TNP-470 and its major metabolites were investigated in AIDS patients enrolled in a phase I dose escalation trial for the treatment of Kaposi's sarcoma. The patients received TNP-470 by 1-h intravenous infusion in dose cohorts of 10, 20, 30, 40, 50 and 70 mg/m2.
J D, Moore +5 more
openaire +2 more sources
Journal of Mass Spectrometry, 1995
AbstractHigh performance liquid chromatography/mass spectrometry using a heat nebulizer atmospheric pressure chemical ionization interface was investigated as a sensitive and selective technique for the chromatographic separation and quantitation of the anti‐angiogenic drug TNP‐470 and its polar metabolites MII and MIV. Upon extraction from plasma, the
Jeff D. Moore, Jean‐Pierre Sommadossi
openaire +1 more source
AbstractHigh performance liquid chromatography/mass spectrometry using a heat nebulizer atmospheric pressure chemical ionization interface was investigated as a sensitive and selective technique for the chromatographic separation and quantitation of the anti‐angiogenic drug TNP‐470 and its polar metabolites MII and MIV. Upon extraction from plasma, the
Jeff D. Moore, Jean‐Pierre Sommadossi
openaire +1 more source
Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol
Bioorganic and Medicinal Chemistry Letters, 2005Deukjoon Kim, Soon Kil Ahn
exaly
A New, Ring Closing Metathesis-Based Synthesis of (−)-Fumagillol
Organic Letters, 2001Pierre Van De Weghe +2 more
exaly
A Concise Synthesis of Fumagillol
Angewandte Chemie - International Edition, 1999Erik Sorensen, David Vosburg
exaly
Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction
Organic Letters, 2014John A Porco +2 more
exaly