Results 141 to 150 of about 12,628 (208)

Modeled Long‐Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto‐Striatal‐Thalamic Circuits

Human Brain Mapping, Volume 47, Issue 10, July 2026.
We used fMRI data from a trial in psychedelic‐naïve healthy participants to show that psilocybin increases dynamic fronto‐striatal‐thalamic activity 4 weeks after dosing. Computational models revealed that reduced structure–function coupling is consistent with the emergence of increased activity dynamics, as well as increased bottom‐up and reduced top ...
Lorenzo Pasquini, Jakub Vohryzek, Anira Escrichs, Yonatan Sanz Perl, Adrian Ponce‐Alvarez, Sebastian Idesis, Manesh Girn, Leor Roseman, Jennifer M. Mitchell, Adam Gazzaley, Morten Kringelbach, David J. Nutt, Taylor Lyons, Robin L. Carhart‐Harris, Gustavo Deco   +14 more
wiley   +1 more source

Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior. [PDF]

Commun Biol
Koszeghy A, Passecker J.
europepmc   +1 more source

Dexmedetomidine Rapidly Relieves Stress‐Induced Hyperalgesia via Presynaptic α2‐Adrenergic Inhibition at Orbitofrontal–Insular Glutamatergic Synapses

MedComm, Volume 7, Issue 7, July 2026.
This study identified a maladaptive OFC–AIC glutamatergic circuit in stress‐induced hyperalgesia induction. This critical circuit provides an α2‐AR‐dependent braking target for dexmedetomidine to alleviate excessive glutamatergic transmission and hyperalgesia. ABSTRACT Dexmedetomidine (Dex), an α2‐adrenergic receptor (α2‐AR) agonist, is widely used for
Hui Rong, Yang‐Xun Zhang, Huijie Zhu, Yinyao Li, Yunfan Hou, Yun‐Yong Xie, Lu‐Yao Li, Bei‐Bei Zhang, Shu‐Tao Xie, Wei Zhang, Qi‐Peng Zhang, Xiao‐Yang Zhang, Jing‐Ning Zhu, Xiaoping Gu, Zhengliang Ma   +14 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Directed cortico-limbic dialogue in the human brain. [PDF]

Nat Commun
van Maren E, Mignardot CG, Widmer R, Friedrichs-Maeder C, Ansó J, Nevalainen P, Fuchs M, Pollo C, Tzovara A, Proix T, Schindler KA, Baud MO.   +11 more
europepmc   +1 more source

A história da riqueza na literatura realista brasileira: O Cortiço em foco

, 2014
MACIEL, Siônio Gomes. A história da riqueza na literatura realista brasileira: O Cortiço em foco. 2014. 36f. Trabalho de Conclusão de Curso (Especialização em Fundamentos da Educação: Práticas Pedagógicas Interdisciplinares EAD) – Universidade Estadual ...
Maciel, Siônio Gomes
core  

Behavior- and Cell Type-Specific Cortico-Striatal Decoupling in a Parkinson's Disease-Like Mouse Model. [PDF]

Adv Sci (Weinh)
Yao XR, Liu Y, Zheng WT, Huang MQ, He KW.   +4 more
europepmc   +1 more source

Abnormal Brain Structural Covariance Networks of Cortical Thickness in Cocaine Use Disorder

Addiction Biology, Volume 31, Issue 7, July 2026.
Cocaine use disorder (CUD) disrupts large‐scale brain network coordination. Using structural covariance network analysis, we found reduced local clustering, impaired rich‐club connectivity, and a shift toward lattice‐like organization in CUD patients, while global network robustness remained preserved. These findings reveal a dissociation between local
Linkai Chen, Youling Li, Jie Chen, Junshen Zhang, Xinyu Ma, Qiuling Cai, Guanghui Bai, Meimei Du   +7 more
wiley   +1 more source

A synaptic locus of song learning. [PDF]

Nature
Schreiner DC, Brudner S, Li A, Pearson J, Mooney R.   +4 more
europepmc   +1 more source

Índios na cidade - territorialidade e exclusão social: uma análise com base na obra “o cortiço”

, 2016
O estudo das relações socioculturais nos grandes centros urbanos do Brasil é amplo e complexo. São várias as abordagens realizadas que versam o entendimento e a compreensão do meio urbano, das relações de classe e poder, de territorialidade e ...
Rodrigues, Beatriz Gomes
core