Results 21 to 30 of about 197,097 (210)

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

When Does Alzheimer's Disease Start? Plasma Aβ42/40 Assays Show Steep Changes at Aβ‐PET Centiloid 15, Mean Age of 66 Years

Annals of Neurology, EarlyView.
Objective Sporadic late‐onset Alzheimer's disease (AD) is characterized by a long pre‐clinical phase where amyloid‐beta (Aβ) and tau begin to accumulate in the brain. The primary objective was to determine the age at which AD starts by finding the average population age when both positron emission tomography (PET) Aβ (Aβ‐PET) and plasma Aβ42/40 become ...
Rodrigo Cánovas, Timothy Cox, Vincent Doré, Pierrick Bourgeat, Jurgen Fripp, Azadeh Feizpour, Rosita Shishegar, Christopher J. Fowler, Simon M. Laws, Tenielle Porter, Stephanie Rainey‐Smith, Leslie M. Shaw, Randall J. Bateman, Yan Li, Ovod Vitaliy, Michael W. Weiner, John C. Morris, Tammie L.S. Benzinger, Suzanne E. Schindler, Akinori Nakamura, Takeshi Iwatsubo, Takeshi Ikeuchi, Takashi Kato, Paul Maruff, Hamid R. Sohrabi, Christopher C. Rowe, Ralph N. Martins, Colin L. Masters, James D. Doecke, for the Alzheimer's Disease Neuroimaging Initiative   +29 more
wiley   +1 more source

Uncertainties in classification system conversion and an analysis of inconsistencies in global land cover products [PDF]

, 2017
In this study, using the common classification systems of IGBP-17, IGBP-9, IPCC-5 and TC (vegetation, wetlands and others only), we studied spatial and areal inconsistencies in the three most recent multi-resource land cover products in a complex ...
De Maeyer, Philippe, Kurban, Alishir, Ma, Mingguo, Zhang, Miao   +3 more
core   +2 more sources

Integrated Assessment of Lipid Oxidation and Off‐Flavor Formation in Plant Protein Powders

Journal of the American Oil Chemists' Society, EarlyView.
Impact of residual lipids on oxylipin and off‐flavor formation in commercial plant proteins: A detailed analysis of precursor‐product relationships by GC‐FID, LC‐MS/MS, and GC‐MS. ABSTRACT The widespread adoption of plant proteins is hindered by their inherent off‐flavors, often linked to lipid oxidation products.
Fernanda Furlan Goncalves Dias, Wellington da Silva Oliveira, Stanislau Bogusz Junior, Ameer Y. Taha   +3 more
wiley   +1 more source

Stochastic delocalization of finite populations

, 2012
Heterogeneities in environmental conditions often induce corresponding heterogeneities in the distribution of species. In the extreme case of a localized patch of increased growth rates, reproducing populations can become strongly concentrated at the ...
Kimura M, Kimura M, Kolmogorov A N, Lukas Geyrhofer, Lynch M, Oskar Hallatschek, Tunnicliffe V, Whitlock M C, Wolff A   +8 more
core   +1 more source

Stellar Populations in Barred Galaxies [PDF]

, 2009
We developed an iterative technique to better characterize stellar populations and the central activity of barred galaxies using evolutionary synthesis codes and OASIS data. The case of NGC5430 is presented here.
A. Pellerin, C. Robert, Drissen, M. Mollá, S. Cantin, É. Brière   +5 more
core   +1 more source

Trabecular bone ontogeny of the human talus

The Anatomical Record, EarlyView.
Abstract Studies of trabecular ontogeny may provide insight into the factors that drive healthy bone development. There is a growing understanding of how the juvenile skeleton responds to these influences; however, gaps in our knowledge remain. This study aims to identify ontogenetic trabecular patterns and regional changes during development within ...
Rebecca A. G. Reid, Catriona Davies, Craig Cunningham   +2 more
wiley   +1 more source

Meteorological and surface heat balance characteristice over different surface condidtions in arid northwest China (HEIFE area) [PDF]

, 2002
Surface meteorological and heat balance were analyzed based on various surface conditions over arid region in northwest China (HEIFE area). The different surface conditions were clearly observed in summer rather than in winter.
Tsukamoto, Osamu, Yang, Qin
core  

Creating space(s) for learning in prison: Developing an andragogical framework

British Educational Research Journal, EarlyView.
Abstract Learning in prison is too often excluded from wider discussions of educational experiences, processes and impact. This paper proposes, for the first time, an iterative andragogical framework to conceptualise learning spaces within prison contexts.
Morwenna Bennallick, Jayne Finlay, Ross Little, Helen Nichols   +3 more
wiley   +1 more source

El oasis arquitectónico. Algunos referentes en la arquitectura turística española [PDF]

, 2006
María Cristina García González, “El oasis arquitectónico. Algunos referentes en la arquitectura turística española”, Ponencia invitada, I Congreso Internacional de Oasis y Turismo sostenible, La Cultura del Oasis, Elche, 14 de diciembre de ...
García González, María Cristina
core