Results 141 to 150 of about 2,031 (173)

Genetic Variation and Sex-Based Differences: Current Considerations for Anesthetic Management. [PDF]

Curr Issues Mol Biol
DiMaria S, Mangano N, Bruzzese A, Bartula B, Parikh S, Costa A.   +5 more
europepmc   +1 more source

Modulation of Multispecific Transporters by Uncaria tomentosa Extract and Its Major Phytoconstituents. [PDF]

Pharmaceutics
Szilvásy N, Lajer P, Horváth A, Veres K, Hohmann J, Schelz Z, Minorics R, Zupkó I, Gáborik Z, Kis E, Temesszentandrási-Ambrus C.   +10 more
europepmc   +1 more source

Circulating low-molecular-weight (poly)phenol metabolites in the brain: unveiling in vitro and in vivo blood–brain barrier transport

Carecho R, Marques D, Carregosa D, Masuero D, Garcia-Aloy M, Tramer F, Passamonti S, Vrhovsek U, Ventura MR, Brito MA, Nunes dos Santos C, Figueira I.   +11 more
europepmc   +1 more source

Polymorphisms in Human Organic Anion-transporting Polypeptide 1A2 (OATP1A2) [PDF]

Journal of Biological Chemistry, 2005
Organic anion-transporting polypeptide 1A2 (OATP1A2) is a drug uptake transporter known for broad substrate specificity, including many drugs in clinical use. Therefore, genetic variation in SLCO1A2 may have important implications to the disposition and tissue penetration of substrate drugs.
Wooin Lee, Guillermo Gervasini
exaly   +3 more sources

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OATP1A2 and OATP2B1 Are Interacting with Dopamine-Receptor Agonists and Antagonists

Molecular Pharmaceutics, 2020
Interaction with the dopaminergic system in the central nervous system is either therapeutically intended or it is a side effect. In both cases, dopamine-receptor agonists (DRA) like the ergoline derivative bromocriptine and dopamine-receptor antagonists (DRAn) like metoclopramide have to cross the blood-brain barrier (BBB).
Anima M Schäfer, Henriette E Meyer Zu Schwabedissen, Stefan Oswald   +2 more
exaly   +3 more sources

Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis

Xenobiotica, 2021
1. OATP1A2 overexpressed is involved in chemotherapy disposition, indicating its role in tumour development and progression. 2. CHIP and siRNA were used to evaluate the status of histone acetylation at the OATP1A2 promoter. The role of OATP1A2 was analysed by gene-set enrichment and overall survival analysis. 3.
Su Zeng
exaly   +3 more sources

Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants

Drug Metabolism and Pharmacokinetics, 2022
Non-synonymous genetic variants of organic anion-transporting polypeptide (OATP) 1A2 with altered transport activity have been identified. Naringin and narirutin, which are found in grapefruit, and their aglycon naringenin inhibit OATP1A2. However, their inhibitory effects on OATP1A2 variants have not been investigated, nor has the influence of their ...
Tokio Morita, Takeshi Akiyoshi, Hiroki Kataoka   +2 more
exaly   +3 more sources

Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic Mice [PDF]

Clinical Cancer Research, 2013
Abstract Purpose: Organic anion-transporting polypeptide (OATP) drug uptake transporters are thought to play an important role in drug pharmacokinetics and toxicokinetics. We aimed to determine the influence of the individual human OATP1B1, OATP1B3, and OATP1A2 transporters on the in vivo disposition of the anticancer drugs ...
Alfred H Schinkel
exaly   +3 more sources

Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier

Xenobiotica, 2012
OATP1A2 is expressed in the luminal membrane of human blood-brain barrier (BBB). The human tissue with the highest OATP1A2 mRNA expression is the brain. We have established a robust BacMam2-OATP1A2 transduced HEK293 system. Among the 36 central nervous system (CNS) marketed drugs tested, hydrophilic triptans, 5-HT(1B/1D) receptor agonists for ...
Fei Wang
exaly   +3 more sources

Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants

Drug Metabolism and Pharmacokinetics, 2022
Little is known about the influence of non-synonymous genetic variations in the organic anion-transporting polypeptide (OATP) 1A2 on the transport kinetics of its substrate fexofenadine. Moreover, the pH-dependency of fexofenadine uptake also remains unclear.
Hongye Han, Takeshi Akiyoshi, Tokio Morita, Hiroki Kataoka, Kazuhiro Katayama, Kodai Yajima, Ayuko Imaoka, Hisakazu Ohtani   +7 more
openaire   +2 more sources