Results 211 to 220 of about 1,391,841 (242)

Fecal Aβ and tau aggregates are elevated in cognitive impairment and reveal peripheral proteopathic alterations. [PDF]

Alzheimers Res Ther
Özdüzenciler P, Müller L, Kara E, Weber MC, Pils M, Rehn F, Bannach O, Fink GR, Willbold D, Barbe MT, Onur OA, Tamgüney G.   +11 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Genetic Risk for Depression Associates with Circulating Immunoregulatory Natural Killer Cells Independent of BMI: An Exploratory Immunophenotyping Study. [PDF]

Cells
Fyka A, Anastasopoulou D, Livadara M, Eliopoulos AG, Gkouskou K.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Associations between maternal adiposity during pregnancy and neonatal brain cortical development. [PDF]

Neuroimage
Na X, Yancey-Ward BL, Xue Y, Glasier CM, Liu Y, Ou X.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Effects of a family home-based intervention on global health and 24h movements: an exploratory family cluster-based approach to childhood obesity. [PDF]

Int J Public Health
Siroux J, Lemay J, Ramos I, Drapeau V, Chaput JP, Vedrine E, Dalmais C, Rousset-Thiry V, Thivel D, Boirie Y, Miolanne M.   +10 more
europepmc   +1 more source

The influence of lean and fat mass on vascular structure and function in youth of varying body mass index percentiles- a comprehensive approach. [PDF]

Front Endocrinol (Lausanne)
Evanoff NG, Dooley JS, Kelly AS, Dengel DR.   +3 more
europepmc   +1 more source

Oxygen cost of breathing and its association with dyspnea in older patients with heart failure with preserved ejection fraction and obesity. [PDF]

J Appl Physiol (1985)
Balmain BN, Mons V, Tomlinson AR, MacNamara JP, Abulimiti A, Leahy MG, Wakeham DJ, Lutz K, Hynan LS, Levine BD, Sarma S, Babb TG.   +11 more
europepmc   +1 more source