Results 81 to 90 of about 1,391,841 (242)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The OB associations of NGC 7217 and UGC 12732

, 1998
We present the first results in an ongoing project to identify objectively OB associations in galaxies with varying luminosities, morphologies and environments.
P. W. Hodge, T. K. Wyder, P. Battinelli, CAPUZZO DOLCETTA, Roberto Angelo   +3 more
core  

OB runaway stars originating in the Vel OB1 association

Astronomy & Astrophysics
Context. OB runaway stars are massive stars moving through interstellar space with a high velocity (up to 200 km s−1). They are produced by dynamical ejections in young massive clusters or by supernova explosions in massive binaries.
Azatyan N., Kaper L., Samsonyan A., Stoop M., Andreasyan D., van den Eijnden J., Nikoghosyan E.   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Availability of olfactory bulb: experience from a British Brain Bank

Arquivos de Neuro-Psiquiatria
The olfactory bulb and tract (OB/OT) are among the earliest structures in the brain to undergo pathological changes in many neurodegenerative conditions.
Suraj Rajan, Linda Parsons, Andrew J Lees, Laura Silveira-Moriyama   +3 more
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Structure And Evolution Of Nearby Ob Associations

, 2007
We present the first results of a comprehensive census of the stellar content of the nearby OB associations based on Hipparcos positions, proper motions and parallaxes for 12842 candidate member stars distributed over 21 fields on the sky.
J. Lub, A. Blaauw, R.S. Le Poole, P.T. de Zeeuw, R. Hoogerwerf, A.G.A. Brown, J.H.J. de Bruijne   +6 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source