Results 101 to 110 of about 46,697 (261)

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source

New therapeutic options for metabolic‐associated steatotic liver disease

British Journal of Clinical Pharmacology, EarlyView.
An increasing number of patients are being diagnosed with metabolic dysfunction‐associated steatotic liver disease (MASLD). MASLD results from disturbances in hepatic lipid metabolism and is associated with an increased risk of cirrhosis and hepatocellular carcinoma and significant extrahepatic morbidity, including cardiovascular disease and ...
Tessa Straatmijer, Midas Mulder
wiley   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Translation and validation of the Persian version of the morbid obesity quality of life questionnaire

BMC Research Notes
Objective Morbid obesity significantly impairs quality of life, leading to increased morbidity, healthcare costs, and longer hospital stays. Generic quality of life instruments may fail to capture the disease-specific challenges experienced by ...
Shima Ghannadi, Maryam Ganjalikhani, Ali Kordi, Ramin Kordi, Kazem Khalagi, Elham Sharafi, Hanieh-Sadat Ejtahed, Mohammad Hossein Pourgharib Shahi, Shirin Hasani Ranjbar   +8 more
doaj   +1 more source

Improved Physical, Emotional, and Social Well-Being in People Living With Obesity Treated With Semaglutide: A Plain Language Summary

Therapeutic Advances in Endocrinology and Metabolism
Summary What is this summary about? Many people live with extra weight or obesity. Semaglutide is a type of weight loss medication for the treatment of obesity. A study published in 2024 reported on the experiences of people taking semaglutide.
Ronette L. Kolotkin, Rajitha K., Henrik Brandi, Julie Hviid Hahn-Pedersen   +3 more
doaj   +1 more source

Hospital‐Level Variations in Outcomes and Readmissions Among Patients With STEMI and Cardiogenic Shock Receiving Mechanical Circulatory Support: Insights From a National Cohort

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The utilization of mechanical circulatory support (MCS) in patients presenting with ST‐elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS) has increased substantially in recent years. However, it remains unclear whether the spectrum of MCS devices available and the type of hospital in which patients are ...
Mukunthan Murthi, Andres Quevedo, Shubhashis Saha, Anisha Memdani, Naveen Baskaran, Aviral Vij   +5 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Baseline Body Mass Index Category and Incident Treated Hypertension in Australian Men: A Linked Prospective Cohort Study Using PBS/MBS Data

Chronic Diseases and Translational Medicine, EarlyView.
Kaplan–Meier hypertension‐free survival by baseline body mass index category, primary adult cohort (men aged ≥ 18 years, n = 12,742). Time since baseline in years is plotted on the horizontal axis and the probability of remaining free of treated hypertension is plotted on the vertical axis. Numbers at risk are shown beneath the plot.
Ebenezer Afrifa‐Yamoah
wiley   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Research Update: A Systematic Review of the Relationship Between Eating Disorder Symptoms and Parental Socioeconomic Status (SES) Among Adolescents

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) have long been viewed as disorders affecting higher socioeconomic groups, yet recent evidence shows they occur across all backgrounds. This systematic review and meta‐analysis aims to evaluate the relationship between parental socioeconomic status (SES) and ED symptoms in adolescents in the general population ...
Lea Steinstad, Alice Schittek, Marcelo R. Cardona Cabrera, Nadia Micali, Nora Trompeter   +4 more
wiley   +1 more source