Results 41 to 50 of about 43,686 (186)

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Health-related quality of life after camp-based family obesity treatment: an RCT

BMJ Paediatrics Open, 2019
Objective To compare the effects of a 2-year camp-based immersion family treatment for obesity with an outpatient family-based treatment for obesity on health-related quality of life (HRQoL) in two generations.Design Randomised controlled trial.Setting ...
Beate Benestad, Tor-Ivar Karlsen, Milada Cvancarova Småstuen, Samira Lekhal, Jens Kristoffer Hertel, Silje Steinsbekk, Ronette L Kolotkin, Rønnaug Astri Ødegård, Jøran Hjelmesæth   +8 more
doaj   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Intestinal fatty acid binding protein is associated with coronary artery disease in long-term type 1 diabetes—the Dialong study

Cardiovascular Diabetology
Background Individuals with type 1 diabetes are at increased risk of accelerated atherosclerosis, causing coronary artery disease (CAD). The underlying mechanisms remain unclear, but new theories proposed are damage of gut mucosa causing leakage and ...
Marte Narum, Ingebjørg Seljeflot, Vibeke Bratseth, Tore Julsrud Berg, Kari Anne Sveen   +4 more
doaj   +1 more source

Socioeconomic inequality in morbid obesity with body mass index more than 40 kg/m2 in the United States and England

SSM: Population Health, 2017
Introduction: This study evaluated socioeconomic inequality in morbid obesity (body mass index, BMI ≥40 kg/m2) through an analysis of population health survey data in the United States (US) and England (UK).
Helen P. Booth, Judith Charlton, Martin C. Gulliford   +2 more
doaj   +1 more source

Effect Differences of Omega‐3 Fatty Acids From Plant Oil and Fish Oil on Human Health

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Omega‐3 fatty acids in plant oil is no less than fish oil on human health. ALA in plant oil takes directly healthy effects without conversion to DHA and EPA. Plant oil can be substitutes for fish oil to support partial ω‐3 fatty acids. For people who cannot afford fish oil, plant oil is also good for public health.
Mengxue Fang, Chunyan Xiang, Liangxiao Zhang, Peiwu Li   +3 more
wiley   +1 more source

Exploring the prevalence and symptom presentation of food addiction among Norwegian bariatric surgery patients: associations with depression, dysregulated eating, and postoperative weight loss

Journal of Eating Disorders
Background Pathological eating and addictive processes are linked to obesity. Food addiction (FA) involves hedonic eating of highly palatable foods, accompanied by addictive symptoms like craving, loss-of-control (LOC) eating, and withdrawal.
Gro Walø-Syversen, Jon Kristinsson, Inger L. Eribe, Øyvind Rø, Camilla Lindvall Dahlgren   +4 more
doaj   +1 more source

Systematic Review and Meta‐Analysis of Short‐ and Long‐Term Outcomes Following Natural Orifice Specimen Extraction for Colon Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Natural orifice specimen extraction (NOSE) in colon cancer surgery raises concerns about intra‐abdominal infection, peritoneal seeding, and local recurrence due to possible tumor cell implantation. This systematic review and meta‐analysis compares complete intracorporeal resection with NOSE versus conventional laparoscopic colon ...
Daichi Kitaguchi, Antonello Forgione, Mariano Giménez, Tatsuya Oda, Jacques Marescaux   +4 more
wiley   +1 more source

Bone mineral density and explanatory factors in children and adults with juvenile dermatomyositis at long term follow-up; a cross sectional study

Pediatric Rheumatology Online Journal, 2021
Background Juvenile dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy in children and adolescents. Both the disease and its treatment with glucocorticoids may negatively impact bone formation.
Henriette Schermacher Marstein, Kristin Godang, Berit Flatø, Ivar Sjaastad, Jens Bollerslev, Helga Sanner   +5 more
doaj   +1 more source