Results 61 to 70 of about 882,867 (351)

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, EarlyView.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source

Low LDL particle levels associate with coronary arteries free from atherosclerosis in long-term type 1 diabetes: the Dialong study

Cardiovascular Diabetology
Background The risk of developing coronary artery disease (CAD) is increased in type 1 diabetes, due to accelerated atherosclerosis. The molecular mechanisms are yet to be unraveled, but potential functional and quantitative abnormalities in lipoproteins
Marte Narum, Jacob Juel Christensen, Kirsten B. Holven, Tore Julsrud Berg, Kari Anne Sveen   +4 more
doaj   +1 more source

Morbidnoe ozhirenie - vozmozhnostikonservativnoy terapii

Ожирение и метаболизм, 2010
Medico-social significance of morbid obesity, occurring in 2-4% of the adult population in Russia, results from the severity of obesity- associated diseases.

doaj   +1 more source

Direct healthcare cost of obesity in brazil: an application of the cost-of-illness method from the perspective of the public health system in 2011. [PDF]

PLoS ONE, 2015
Obesity is a global public health problem and a risk factor for several diseases that financially impact healthcare systems.To estimate the direct costs attributable to obesity (body mass index {BMI} ≥ 30 kg/m2) and morbid obesity (BMI ≥ 40 kg/m2) in ...
Michele Lessa de Oliveira, Leonor Maria Pacheco Santos, Everton Nunes da Silva   +2 more
doaj   +1 more source

Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2017
Background and objective Studies are needed in order to inform recommendations for interpreting albumin levels among obese individuals without known medical conditions associated with hypoalbuminemia.
R. Mosli, H. Mosli
semanticscholar   +1 more source

Obesity and chronic kidney disease: A current review

Obesity Science & Practice, 2022
Obesity poses significant challenges to healthcare globally, particularly through its bi‐directional relationship with co‐morbid metabolic conditions such as type 2 diabetes and hypertension.
S. Nawaz, R. Chinnadurai, S. Al-Chalabi, P. Evans, P. Kalra, A. Syed, S. Sinha   +6 more
semanticscholar   +1 more source

Development of Age‐ and Sex‐Specific Metabolomics‐Based Biological Ageing Clocks for 10‐Year Mortality Prediction

Advanced Science, EarlyView.
Metabolomics‐based ageing clocks developed using blood biomarkers from over 215 000 European adults, improved the prediction of 10‐year all‐cause mortality compared to traditional models. Biological age acceleration is associated with higher mortality risk, as each additional year of metabolic age corresponded to at least 8% increased risk. These tools
Lei Peng, Ruijie Xie, Bernd Holleczek, Hermann Brenner, Ben Schöttker   +4 more
wiley   +1 more source

Trigonelline Improves Metabolism and Cardiac Function of HFpEF Mice Via Gut Microbiome Alterations‐Mediated AMPK Activation

Advanced Science, EarlyView.
Metabolomics analyses reveal that trigonelline is markedly reduced in HFpEF hearts. Trigonelline supplementation alleviates metabolic disorders and improves cardiac function in HFpEF mice via gut microbiota‐mediated AMPK activation. Abstract Heart failure with preserved ejection fraction (HFpEF) is a prevalent end‐manifestation of cardiovascular ...
Zhe Cheng, Xiaowen Wang, Jiang Yu, Xiaorong Li, Qing Tang, Can Qu, Ding Yang, Yuanjing Li, Yong Xia, Yongzheng Guo   +9 more
wiley   +1 more source

Early Maladaptive Schemas and Cognitive Distortions in Adults with Morbid Obesity: Relationships with Mental Health Status

Behavioral Sciences, 2017
Dysfunctional cognitions may be associated with unhealthy eating behaviors seen in individuals with obesity. However, dysfunctional cognitions commonly occur in individuals with poor mental health independently of weight.
Felipe Q. da Luz, Amanda Sainsbury, Phillipa Hay, Jessica A. Roekenes, Jessica Swinbourne, Dhiordan C. da Silva, Margareth da S. Oliveira   +6 more
doaj   +1 more source

A surgical model of short bowel syndrome induces a long-lasting increase in pancreatic beta-cell mass [PDF]

, 2015
Several surgical techniques are used nowadays as a severe treatment for obesity and diabetes mellitus type 2. These techniques are aggressive due to drastic changes in the nutrient flow and non-reversible modifications on the digestive tube.
Aguilar Diosdado, Manuel, Camacho Ramírez, Alonso, Lechuga Sancho, Alfonso María, Prada Oliveira, José Arturo, Pérez Arana, Gonzalo Martín, Sancho Maraver, Eva, Segundo Iglesias, María del Carmen   +6 more
core   +2 more sources