Results 71 to 80 of about 882,867 (351)

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Health-related quality of life after camp-based family obesity treatment: an RCT

BMJ Paediatrics Open, 2019
Objective To compare the effects of a 2-year camp-based immersion family treatment for obesity with an outpatient family-based treatment for obesity on health-related quality of life (HRQoL) in two generations.Design Randomised controlled trial.Setting ...
Beate Benestad, Tor-Ivar Karlsen, Milada Cvancarova Småstuen, Samira Lekhal, Jens Kristoffer Hertel, Silje Steinsbekk, Ronette L Kolotkin, Rønnaug Astri Ødegård, Jøran Hjelmesæth   +8 more
doaj   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Intestinal fatty acid binding protein is associated with coronary artery disease in long-term type 1 diabetes—the Dialong study

Cardiovascular Diabetology
Background Individuals with type 1 diabetes are at increased risk of accelerated atherosclerosis, causing coronary artery disease (CAD). The underlying mechanisms remain unclear, but new theories proposed are damage of gut mucosa causing leakage and ...
Marte Narum, Ingebjørg Seljeflot, Vibeke Bratseth, Tore Julsrud Berg, Kari Anne Sveen   +4 more
doaj   +1 more source

Socioeconomic inequality in morbid obesity with body mass index more than 40 kg/m2 in the United States and England

SSM: Population Health, 2017
Introduction: This study evaluated socioeconomic inequality in morbid obesity (body mass index, BMI ≥40 kg/m2) through an analysis of population health survey data in the United States (US) and England (UK).
Helen P. Booth, Judith Charlton, Martin C. Gulliford   +2 more
doaj   +1 more source

The TrueBlue study : is practice nurse-led collaborative care effective in the management of depression for patients with heart disease or diabetes? [PDF]

, 2009
Background: In the presence of type 2 diabetes (T2DM) or coronary heart disease (CHD), depression is under diagnosed and under treated despite being associated with worse clinical outcomes.
Coates, Michael, Dunbar, James, Leahy, Robert, Morgan, Mark, Reddy, Prasuna   +4 more
core   +3 more sources

Effect Differences of Omega‐3 Fatty Acids From Plant Oil and Fish Oil on Human Health

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Omega‐3 fatty acids in plant oil is no less than fish oil on human health. ALA in plant oil takes directly healthy effects without conversion to DHA and EPA. Plant oil can be substitutes for fish oil to support partial ω‐3 fatty acids. For people who cannot afford fish oil, plant oil is also good for public health.
Mengxue Fang, Chunyan Xiang, Liangxiao Zhang, Peiwu Li   +3 more
wiley   +1 more source

Exploring the prevalence and symptom presentation of food addiction among Norwegian bariatric surgery patients: associations with depression, dysregulated eating, and postoperative weight loss

Journal of Eating Disorders
Background Pathological eating and addictive processes are linked to obesity. Food addiction (FA) involves hedonic eating of highly palatable foods, accompanied by addictive symptoms like craving, loss-of-control (LOC) eating, and withdrawal.
Gro Walø-Syversen, Jon Kristinsson, Inger L. Eribe, Øyvind Rø, Camilla Lindvall Dahlgren   +4 more
doaj   +1 more source

The Benefit of Sleeve Gastrectomy in Obese Adolescents on Nonalcoholic Steatohepatitis and Hepatic Fibrosis [PDF]

, 2017
Objective To determine whether bariatric surgery is effective for the treatment of nonalcoholic steatohepatitis (NASH) in adolescence, we compared the efficacy of laparoscopic sleeve gastrectomy (LSG) with that of lifestyle intervention (nonsurgical ...
Alisi, Anna, Baumann, Ulrich, Caccamo, Romina, Cutrera, Renato, De Peppo, Francesco, De Stefanis, Cristiano, Giordano, Ugo, Manco, Melania, Mosca, Antonella, Nobili, Valerio, Silecchia, Gianfranco   +10 more
core   +1 more source