Results 181 to 190 of about 940,991 (254)

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Correction: The nature of the relationship between obesity and mental health: an IMI2 SOPHIA qualitative study. [PDF]

Int J Obes (Lond)
Farrell E, Nadglowski J, Hollmann E, le Roux CW, McGillicuddy D.   +4 more
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Application and Presentation of the Edmonton Obesity Staging System in a Lifestyle Medicine Clinic: A Cross-Sectional Study. [PDF]

J Epidemiol Glob Health
Abdoh DS, Al Gareeb GA, Kofi M, Alolaiwi L, Almotiri SS, Konswa AA.   +5 more
europepmc   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Social Perception of Obesity - A 2025 Nationwide Cross-Sectional Survey Among Adults in Poland. [PDF]

Int J Public Health
Sękowski KB, Mazurek A, Grześczyk-Nojszewska Z, Jankowski M, Kamińska A, Olearczyk A, Silczuk A, Grudziąż-Sękowska J.   +7 more
europepmc   +1 more source

Multi‐Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs

Advanced Science, EarlyView.
Integrated multi‐omics across pig breeds and tissues reveals key principles of post‐transcriptional translational regulation and their contribution to trait formation. A gene network framework integrating transcriptomic and translatomic data is developed and applied to elucidate the genetic basis of meat production, offering new insights into mammalian
Chao Wang, Yuanyuan Zhang, Choulin Chen, Xiaoxian Xu, Shenghua Qin, Junyan Qi, Yongzhou Bao, Huiming Li, Ruipu Chen, Weigang Zheng, Zhilong Chen, Lingzhao Fang, Yunxiang Zhao, Yuwen Liu   +13 more
wiley   +1 more source

Infant Diet Is Associated With BMI Later in Childhood: A Nation-Wide Mother-Child Cohort Study in Iceland (ICE-MCH). [PDF]

Matern Child Nutr
Jonsdottir J, Thorisdottir B, Einarsdottir K, Thorsdottir I.   +3 more
europepmc   +1 more source

A smart headband for multimodal physiological monitoring in human exercises

Advanced Science, EarlyView.
A novel smart headband incorporating a thermal‐sensation‐based electronic skin is presented for continuous and accurate multimodal physiological monitoring, including pulse waveforms, total metabolic energy expenditure, heart rate, and forehead temperature, across both static and dynamic daily activities.
Shiqiang Liu, Guanxing Chen, Jingyi Peng, Shuo Tian, Qian Mao, Caise Wei, Jinfeng Yuan, Rong Zhu   +7 more
wiley   +1 more source

Silk Fibroin Nanoparticles as a Drug Delivery System of 3,3′-Diindolylmethane with Potential Antiobesogenic Activity

ACS Omega
Calef Sánchez-Trasviña, Helen Y. Lorenzo-Anota, Aleyda M. Escobar-Fernández, David Lezama-Aguilar, Adriana Morales-Martínez, Ana Vélez-Barceló, Jorge Benavides, Omar Lozano, Marco Rito-Palomares, Karla Mayolo-Deloisa   +9 more
doaj   +1 more source