Results 241 to 250 of about 2,007,139 (344)

Investigating multidimensional associations between obesity-related traits and brain health, and identifying potential mechanisms. [PDF]

Medicine (Baltimore)
Chen S, Wen J, Tan Z, Chen Y, Xia Z, Liu H.   +5 more
europepmc   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

A Cross-Sectional Study Investigating the Relationship Between the <i>FTO</i> Gene Polymorphism in Relation to Obesity Traits and Vitamin D Status in Adolescence. [PDF]

Obes Sci Pract
Al-Serri A, Al-Temaimi RA, Al-Taiar A, Shaban L, Al-Sabah R, Rahman A, Ziyab AH.   +6 more
europepmc   +1 more source

Coreopsis tinctoria improves energy metabolism in obese hyperglycemic mice [PDF]

Bingxin Huangfu, Minglan Yang, Jiajia Xu, Ruxin Gao, Yanzhou Hu, Yijia Zhao, Kunlun Huang, Xiaoyun He   +7 more
openalex   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Multidisciplinary care of pediatric obesity and its impact on sleep: a review. [PDF]

Front Sleep
Inja R, Cielo C.
europepmc   +1 more source

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

Advanced Science, EarlyView.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo   +10 more
wiley   +1 more source

Prevalence, time trends and associated factors of adult overweight and obesity in 36 countries in the WHO African region from 2003 to 2022: a study of 54 WHO STEPS surveys representing 156 million adults. [PDF]

BMJ Glob Health
Agboyibor KM, Nambiema A, Golestani A, Okeibunor J, Diallo CBB, Jouven X, Dangou JM, Farzadfar F, Empana JP, African STEPS Group.   +9 more
europepmc   +1 more source