Results 241 to 250 of about 1,922,582 (355)

Are the Obese Metabolically Different?

, 1956
S. O. Waife
openalex   +1 more source

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff   +17 more
wiley   +1 more source

Adipose Tissue Macrophages as Initiators of Exacerbated Periodontitis in Estrogen‐Deficient Environments via the Amplifier Extracellular Vesicles

Advanced Science, EarlyView.
Chronic systemic inflammation, worsened by estrogen deficiency, underlies and exacerbates periodontitis. Proinflammatory macrophages within visceral adipose tissue are hyperactivated due to hyper‐DNA methylation, releasing small extracellular vesicles (sEVs) similar to those of their parent cells.
Danfeng Li, Tian Yang, Yuqian Li, Xinwei Lyu, Cheng Hu, Jiayin Yan, Jiali Tan   +6 more
wiley   +1 more source

CGRP‐Loaded ROS‐Responsive Hydrogel Restores Neuro‐Angiogenic Signaling to Promote Bone Regeneration in Diabetes‐Associated Periodontitis

Advanced Science, EarlyView.
This study shows that diabetes damages sensory nerve fibers, especially CGRP‐positive ones, in the periodontium and disrupts autophagy in trigeminal ganglion neurons, affecting bone homeostasis by inhibiting type H vessel formation. To address this, CGRP@PVA/tsPBA hydrogels are developed to release CGRP in response to ROS, which binds to endothelial ...
Chaoning Zhan, Qingyi Dai, Jianhan Ren, Lijian Jin, Weiping Wang, Zhou Ye, James Kit Hon Tsoi, Yifan Lin   +7 more
wiley   +1 more source

Association between pediatric obesity and foot morphology: insights from a large-scale cross-sectional study using photogrammetry. [PDF]

BMC Pediatr
Büyükçelebi H, Açak M, Eken Ö, Doğaner A, Özen G, Ardigò LP.   +5 more
europepmc   +1 more source

The Total Work of Breathing in Normal and Obese Men*

, 1964
John T. Sharp, J. P. Henry, Stanford K. Sweany, William R. Meadows, Raymond J. Pietras   +4 more
openalex   +1 more source

Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity

Advanced Science, EarlyView.
This review explores the complex and self‐reinforcing cycle of mechanical stress, inflammation, and altered vascularity in tendinopathy—a common, painful tendon disorder. It integrates current findings on cellular, molecular, and biomechanical mechanisms, highlighting how mechanical overload, inflammatory signals, and abnormal blood vessel behavior ...
Renate Gehwolf, Herbert Tempfer, Nevra Pelin Cesur, Andrea Wagner, Andreas Traweger, Christine Lehner   +5 more
wiley   +1 more source

The Impact of Sarcopenic Obesity on Weight Loss Outcomes and Recurrent Weight Gain Following Laparoscopic Sleeve Gastrectomy. [PDF]

Diabetes Metab Syndr Obes
Wang X, Shu X, Pei W, Yuan C, Su X, Xiong J, Chen W, Zhang G, Jie Z, Liu Y.   +9 more
europepmc   +1 more source

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA

Advanced Science, EarlyView.
This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li, Julian Aurelio Marschner, Yoshihiro Kusunoki, Ningxin Zhang, Xiaoxin Li, Hao Deng, Zhibo Zhao, Kanako Watanabe‐Kusunoki, Zhihui Zhu, Yan Xu, Stefanie Steiger, Maciej Lech, Katalin Susztak, Christian Schulz, Hans‐Joachim Anders   +14 more
wiley   +1 more source

Supervised machine learning algorithms for the classification of obesity levels using anthropometric indices derived from bioelectrical impedance analysis. [PDF]

Sci Rep
Yáñez-Sepúlveda R, Vásquez-Bonilla A, Olivares R, Olivares P, Zavala-Crichton JP, Hinojosa-Torres C, Muñoz-Strale C, Giakoni-Ramírez F, de Souza-Lima J, Páez-Herrera J, Olivares-Arancibia J, Reyes-Amigo T, Cortés-Roco G, Hurtado-Almonacid J, Guzmán-Muñoz E, Aguilera-Martínez N, López-Gil JF, Becerra-Patiño BA, Paucar-Uribe JD, Garcia-Carrillo E, Clemente-Suárez VJ.   +20 more
europepmc   +1 more source