Results 261 to 270 of about 2,007,139 (344)

Incretin-based therapies for obesity and disordered eating: optimising care in general practice. [PDF]

Fam Med Community Health
Atlantis E, Wu R, Dixon J.
europepmc   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Early-life obesity as a risk factor for central precocious puberty - A commentary on "Incidence of central precocious puberty and the role of body mass index in Korea&quot. [PDF]

Ann Pediatr Endocrinol Metab
Lee HS.
europepmc   +1 more source

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

Silk Fibroin Nanoparticles as a Drug Delivery System of 3,3′-Diindolylmethane with Potential Antiobesogenic Activity

ACS Omega
Calef Sánchez-Trasviña, Helen Y. Lorenzo-Anota, Aleyda M. Escobar-Fernández, David Lezama-Aguilar, Adriana Morales-Martínez, Ana Vélez-Barceló, Jorge Benavides, Omar Lozano, Marco Rito-Palomares, Karla Mayolo-Deloisa   +9 more
doaj   +1 more source

Association between childhood obesity and polycystic ovary syndrome: a two-sample Mendelian randomization study. [PDF]

Eat Weight Disord
Wei S, Wang Y, Liu N, Zhao R.
europepmc   +1 more source

Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes

Advanced Science, EarlyView.
Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako, Sergio Li Calzi, Julia G. Behnsen, Ram Prasad, Magdalena Blaszkiewicz, Yvonne Adu‐Rutledge, Robert F. Rosencrans, Jason L. Floyd, Ashley Rennhack, Denise Stanford, Anna Lin, Todd A. Lydic, Carl M. Sheridan, Michael E. Boulton, Kristy L. Townsend, Julia V. Busik, Maria B. Grant   +16 more
wiley   +1 more source

What role will physiological resilience play in brown-white fat dynamic in obesity management? [PDF]

Front Pharmacol
Zayachkivska O, Kovalchuk I, Muzyka I, Savytska M.   +3 more
europepmc   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

A comprehensive analysis of oxytocin: a potential brain-based treatment to regulate obesity. [PDF]

Front Endocrinol (Lausanne)
Alsayegh AA, Ashfaq F, Bajahzer M, Alshaharani MY, Almutairi AS, Khan MI, Alhomaid RM, Beg MMA.   +7 more
europepmc   +1 more source