Results 261 to 270 of about 1,922,582 (355)

Outbreak of Severe Obesity and Metabolic Complications in Children and Adolescents Using the Korea National School Health Examination (KNSHE) From 2017 to 2021. [PDF]

J Korean Med Sci
Kim KH, Lee HA, Choi JE, Mun E, Lee R, Park H, Kim HS.   +6 more
europepmc   +1 more source

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

Advanced Science, EarlyView.
In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo, Yifan Feng, Jiajie Min, Yan Zhao, Ziming Zhu, Lijun Sun, Hao Yin, Yue Yin, Weizhen Zhang   +8 more
wiley   +1 more source

The Role of Adipokines and Gene Polymorphisms in the Development of Obesity- Induced Depression. [PDF]

Curr Obes Rep
Ercan SN, Sanlier N.
europepmc   +1 more source

Polyphenol‐Based Functional Materials: Structural Insights, Composite Strategies, and Biomedical Applications

Advanced Science, EarlyView.
This schematic representation illustrates the interaction mechanisms between polyphenolic compounds and various materials (metals, proteins, polysaccharides, alkaloids, etc.). And explains the potential clinical application value of these materials (nanoparticles, coatings, films, capsules, and hydrogels constructed using polyphenols) in the fields of ...
Songwen Xue, Wen Tan, Shuifang Mao, Haibo Pan, Xingqian Ye, Natthawuddhi Donlao, Jinhu Tian   +6 more
wiley   +1 more source

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

Editorial: Nutritional management of childhood obesity and related diseases. [PDF]

Front Nutr
Giaginis C, Papadopoulou SK.
europepmc   +1 more source

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

Advanced Science, EarlyView.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu, Jia Yan, Yuyan Zhang, Xiaozhi Ming, Siqi Chen, Zhichao Zou, Nianjie Feng, Jianbo Xiao   +7 more
wiley   +1 more source

Approach to the Patient: Low Testosterone Concentrations in Men With Obesity.

J Clin Endocrinol Metab
Muir CA, Wittert GA, Handelsman DJ.
europepmc   +1 more source

From Overweight to Severe Obesity: Physical Activity and Behavioural Profiles in a Large Clinical Cohort. [PDF]

J Funct Morphol Kinesiol
Campoli F, Padua E, Caprioli L, Edriss S, Annino G, Bonaiuto V, Lombardo M.   +6 more
europepmc   +1 more source