Results 81 to 90 of about 825,693 (259)
BMC Public Health, 2016 Background Measuring and monitoring the true prevalence of risk factors for chronic conditions is essential for evidence-based policy and health service planning.
Karen Louise Peterson +4 more
doaj +1 more source
Advanced Science, EarlyView.USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang +16 more
wiley +1 more source
Chchd10: A Novel Metabolic Sensor Modulating Adipose Tissue Homeostasis
Advanced Science, EarlyView.Chchd10 is a novel regulator of adipose tissue (AT) homeostasis upon excess energy intake. Rapid Chchd10 reduction in response to high‐fat diet induction promotes adipogenesis in subcutaneous AT to store excess energy. On the other hand, sustained Chchd10 reduction protects visceral AT from 4‐HNE‐induced adipocyte dysfunction, attenuating the ...
Xiaoping Wu +11 more
wiley +1 more source
Advanced Science, EarlyView.Drug abuse exacerbates cholesterol and bile acids burden, causing liver injury. Geniposidic acid targets FXR Ser332 and His447, together with SRC2‐3 recruitment and activated FXR nuclear translocation. Geniposidic acid‐activated FXR can upregulate CYPs to accelerate bile acids clearance and activate miR‐19a‐3p to suppress LXR‐mediated cholesterol ...
Minqi Fan +8 more
wiley +1 more source
Eating and Weight DisordersPurpose Bariatric surgery (BS), an effective treatment for severe obesity and its comorbidities, may result in micronutrient and vitamin deficiencies.
Alessio Basolo +20 more
doaj +1 more source
Advanced Science, EarlyView.This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu +38 more
wiley +1 more source
Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population
Advanced Science, EarlyView.This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen +16 more
wiley +1 more source
Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 71-80, January 2023., 2023 Kaplan‐Meier plot for relapse‐free survival (RFS) after propensity score (PS) matching. Abstract Aim Whether a laparoscopic procedure can contribute to the improvement of clinical outcomes in obese patients with stage II/III rectal cancer compared to an open procedure remains unclear.
Tomonori Akagi +13 more
wiley +1 more source
Nutritional Deficiencies in Morbid Obese Patients Before and After Laparoscopic Sleeve Gastrectomy
The Turkish Journal of Gastroenterology, 2022 Ozan Şen +3 more
doaj +1 more source
Advanced Science, EarlyView.Embelin cotargets SHP2 to disrupt the SHP2/GRB2/SOS complex, inhibiting cancer‐related signaling pathways such as MAPK, (PI3K)/AKT pathway, and XIAP to induce apoptosis signaling pathway, respectively, leading to synthetic lethality in KRAS‐mutant NSCLC cells both in vivo and in vitro.
Nai‐jie Fu +8 more
wiley +1 more source