Results 101 to 110 of about 408,324 (314)

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Human‐Centered Innovation: Precision Nutrition and the Future of Food

Advanced Science, EarlyView.
ABSTRACT Nutritional science is moving beyond one‐size‐fits‐all recommendations toward more precise and personalized approaches, yet its implementation pathway remains unclear. This paper proposes a human‐centered precision nutrition framework that highlights the central roles of artificial intelligence (AI), food innovation, and human agency.
Shanshan Zhang, Yonggan Sun, Jiaqi Jiang, Shaoping Nie   +3 more
wiley   +1 more source

Obesity: pathophysiology and treatment [PDF]

, 2017
Obesity is a complex, multifactorial condition characterized by excess body fat. It is one of the leading preventable causes of death worldwide. It must be viewed as a chronic disorder.
Schwarzmann, Liran
core  

Are Future Doctors Ready for the Post-Pandemic Obesity Surge? A Mixed-Methods Pilot Study

International Medical Education
Obesity is a global epidemic, posing intricate health dilemmas with wide-reaching ramifications. Despite its rising prevalence, obesity often receives inadequate attention in medical training, which is hypothesized to influence obesity management.
Desiree’ Sant, Andrea Cuschieri, Sarah Cuschieri   +2 more
doaj   +1 more source

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source

Escalating prevalence of comorbid obesity and binge eating : 20-year cross sectional data from South Australia from 1995 to 2015 [PDF]

, 2017
Obesity and eating disorders are often studied and treated separately. However, examination of the comorbid occurrence of these two public health concerns is important because eating disorder behaviours are known to contribute to obesity onset and ...
Sainsbury, Amanda, Luz, Felipe Q. da, Touyz, Stephen W., Hay, Phillipa (R12066), Mannan, Haider R. (R18333)   +4 more
core  

USING ACCELEROMETERS AS A METHOD FOR IMPROVING COMPLIANCE WITH PHYSICAL ACTIVITY RECOMMENDATIONS IN THE TREATMENT OF OBESITY IN CHILDREN

Health Problems of Civilization, 2023
Marian J. Stelmach, Piotr Protas, Edyta Tenderenda-Banasiuk, Elżbieta Kuroczycka-Saniutycz, Anna Wasilewska, Marta Lemiesz   +5 more
doaj   +1 more source

Glucagon-like Peptide-1 Receptor Agonists in the Real World: Are Clinical Trials Reproducible? A Spanish Pilot Study

Obesities
Introduction: Obesity is a chronic, multifactorial disease associated with significant metabolic and cardiovascular complications. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as effective pharmacological options for weight ...
Olatz Vergniory-Trueba, Carlos Treceño-Lobato   +1 more
doaj   +1 more source

Assessing the efficacy of herbal supplements for managing obesity: A comprehensive review of global clinical trials [PDF]

Iranian Journal of Basic Medical Sciences
Obesity remains a significant worldwide health concern, and further research into other strategies, including herbal weight-loss medications, is necessary.
Mahboobeh Ghasemzadeh Rahbardar, Gordon A Ferns, Majid Ghayour Mobarhan   +2 more
doaj   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source