Results 91 to 100 of about 2,232,782 (306)

Interplay of glycated hemoglobin and traditional risk factors for the risk of atherosclerotic cardiovascular disease and all-cause mortality in people without diabetes

Cardiovascular Diabetology
Background To assess the impact of glycated hemoglobin A1c (HbA1c) in individuals without diabetes and at the extremes of cardiovascular risk factor (CVRF) burden on the incidence of atherosclerotic cardiovascular disease (ASCVD) and all-cause mortality.
Soroush Masrouri, Amirhossein Hasanpour, Navid Ebrahimi, Farzad Hadaegh   +3 more
doaj   +1 more source

Early life risk factors for obesity in childhood: cohort study [PDF]

, 2005
Objective: To identify risk factors in early life (up to 3 years of age) for obesity in children in the United Kingdom. Design: Prospective cohort study. Setting: Avon longitudinal study of parents and children, United Kingdom.
Ahmad R Dorosty, Pauline M Emmett, Steer, CD, I Rogers, Dorosty, A.R, Armstrong, J, Rogers, IS, Steer, Colin, Ness, AR, Rodgers, I., Sherriff, AM, Reilly, J.J., John J Reilly, Reilly, John J., Emmett, Pauline M., Emmett, PM, Sherriff, Andrea, Armstrong, J., A Ness, Rogers, I., Julie Armstrong, Andrea Sherriff, Colin Steer, Emmett, P.M., Dorosty, Ahmad R., Ness, A., Sherriff, A., Steer, C., Rogers, Imogen, Armstrong, Julie, Dorosty, AR, Reilly, John J, Reilly, JJ, Dorosty, A.R., Ness, A   +34 more
core   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Dietary and lifestyle inflammation scores and incidence of cardiovascular disease and heart failure: evidence from a longitudinal cohort

Nutrition Journal
Background We investigated the associations of dietary and lifestyle inflammation scores (DIS and LIS) with the incidence of all cardiovascular disease (CVD) events, its different subtypes, including hard CVD, stroke, myocardial infarction (MI), as well ...
Azra Ramezankhani, Amir Abdi, Parto Hadaegh, Farzad Hadaegh   +3 more
doaj   +1 more source

Wisconsin Obesity Prevention Efforts (2008-2013) [PDF]

The Centers for Disease Control and Prevention\u2019s (CDC) Division of Nutrition, Physical Activity, and Obesity provided support (training, technical assistance, data, funds) to the Wisconsin Department of Health Services to prevent and control ...

core  

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Characteristics of US Health Care Providers Who Counsel Adolescents on Sports and Energy Drink Consumption

International Journal of Pediatrics, 2014
Objective. To examine the proportion of health care providers who counsel adolescent patients on sports and energy drink (SED) consumption and the association with provider characteristics. Methods.
Nan Xiang, Holly Wethington, Stephen Onufrak, Brook Belay   +3 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source