Results 1 to 10 of about 6,389 (114)

Clinical and biological relevance of objectively-defined subtle cognitive decline in Alzheimer’s disease: a narrative review of neuroimaging, biomarker, and clinical progression studies [PDF]

The Journal of Prevention of Alzheimer's Disease
Preclinical Alzheimer’s Disease stages represent possible targets for disease-modifying intervention as well as opportunity for early identification of risk for future decline.
Amanda I. Gonzalez, Jairo E. Martinez, Averi Giudicessi, Meredith Rowe, Vivian Ku, Catarina Tristão-Pereira, Bing He, Vincent Malotaux, Yakeel T. Quiroz   +8 more
doaj   +2 more sources

Multimodal biomarker characterization of amnestic objective subtle cognitive decline in aging and preclinical Alzheimer’s disease [PDF]

The Journal of Prevention of Alzheimer's Disease
Background: The objective of this study was to provide a multimodal biomarker characterization of amnestic objective subtle cognitive decline (obj-SCD) in aging and preclinical Alzheimer’s disease (AD). Methods: Prospective observational study; data from
David López-Martos, Raffaele Cacciaglia, Marc Suárez-Calvet, Gemma Salvadó, Mahnaz Shekari, Armand González-Escalante, Marta Milà-Alomà, Anna Brugulat-Serrat, Carolina Minguillon, Matteo Tonietto, Edilio Borroni, Gregory Klein, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides   +18 more
doaj   +2 more sources

Embodied simulations improve memory, but which is the most effective? The crucial role of action observation and its dynamic interplay with motor imagery ability [PDF]

Frontiers in Psychology
Literature has shown that memory can be influenced by sensorimotor simulations at encoding as those involved in motor imagery (MI), action observation (AO), or affordances elicited by visual object presentation (OBJ).
Mara Stockner, Giuliana Mazzoni, Giuliana Mazzoni, Ivan Enrici, Francesco Ianì, Francesco Ianì   +5 more
doaj   +2 more sources

Mixed reality-guided intraoperative visual support for combined intracavitary and interstitial brachytherapy for cervical cancer [PDF]

Technical Innovations & Patient Support in Radiation Oncology
Purpose: This study aimed to develop and evaluate a mixed reality-guided intraoperative visual support system for safe and accurate needle applicator insertion for combined intracavitary and interstitial brachytherapy (IC/IS-BT). Materials and Methods: A
Ryuta Hirai, Tomohiro Ohta, Mitsunobu Igari, Yu Kumazaki, Jun Watanabe, Keita Tsukahara, Misaki Iino, Yasuhiro Ryuno, Tomomi Aoshika, Satoshi Saito, Takanori Abe, Shin-ei Noda, Shingo Kato   +12 more
doaj   +2 more sources

Reliability and validity analysis of the Chinese version of the Quick Dementia Rating System (QDRS) [PDF]

BMC Geriatrics
Background Alzheimer’s disease (AD) is one of the most common chronic diseases among the elderly. The Quick Dementia Rating System (QDRS) is a recognized cognitive assessment tool.
Hang Su, Jiehua Zhu, Yifan Wang, Jun Jin, Qihao Guo   +4 more
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Tau levels are higher in objective subtle cognitive decline but not subjective memory complaint

Alzheimer’s Research & Therapy, 2022
Background The 2018 NIA-AA Alzheimer’s Disease (AD) Research Framework states that subtle cognitive decline in cognitively unimpaired individuals can be measured by subjective reports or evidence of objective decline on neuropsychological measures.
Kelsey R. Thomas, Alexandra J. Weigand, Lauren C. Edwards, Emily C. Edmonds, Katherine J. Bangen, Gema Ortiz, Kayla S. Walker, Mark W. Bondi, for the Alzheimer’s Disease Neuroimaging Initiative   +8 more
doaj   +1 more source

142 Using evaluation methods to improve evaluation processes: Creation and implementation of a new continuous improvement process at Duke Univ. Clinical and Translational Science Institute (CTSI)

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: (1) Assess challenges with our current continuous improvement processes via stakeholders. (2) Implement a revised continuous improvement process.
Jessica Sperling, Stella Quenstedt, Joe McClernon   +2 more
doaj   +1 more source

Objective subtle cognitive decline and plasma phosphorylated tau181: Early markers of Alzheimer's disease‐related declines

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction Objectively‐defined subtle cognitive decline (Obj‐SCD) and plasma phosphorylated‐tau181 (p‐tau181) are promising early Alzheimer's disease (AD) markers.
Kelsey R. Thomas, Katherine J. Bangen, Emily C. Edmonds, Alexandra J. Weigand, Kayla S. Walker, Mark W. Bondi, Douglas R. Galasko, for the Alzheimer's Disease Neuroimaging Initiative   +7 more
doaj   +1 more source

Local Functional MR Change Pattern and Its Association With Cognitive Function in Objectively-Defined Subtle Cognitive Decline

Frontiers in Aging Neuroscience, 2021
Introduction: To identify individuals with preclinical cognitive impairment, researchers proposed the concept of objectively-defined subtle cognitive decline (Obj-SCD).
Liang Cui, Zhen Zhang, Chun-Yi Zac Lo, Qihao Guo   +3 more
doaj   +1 more source

Deep Learning-Based Detection of Articulatory Features in Arabic and English Speech

Sensors, 2021
This study proposes using object detection techniques to recognize sequences of articulatory features (AFs) from speech utterances by treating AFs of phonemes as multi-label objects in speech spectrogram.
Mohammed Algabri, Hassan Mathkour, Mansour M. Alsulaiman, Mohamed A. Bencherif   +3 more
doaj   +1 more source