Results 121 to 130 of about 5,434,710 (294)
Russian Journal of Economics and Law, 2008 The article views the notion of objective part of corpus delicti and proves the high social threat of ecological crimes. The author suggests to combine all the functioning environmental regulations into one normative legal act, which would regulate the ...
A. Zartdinova
doaj
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
CRIMES AGAINST FAMILY AND NON-ADULTS IN THE SYSTEM OF SPECIAL PART OF THE RUSSIAN CRIMINAL LAW
Russian Journal of Economics and Law, 2007 The work presents juridical analysis of the corpus delicti included into Chapter 20 of the Russian Federation Criminal Law. It gives the author's viewpoints concerning the objects, objective parts, subjective parts and subjects of the mentioned crimes.
N. N. Marshakova
doaj
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
FOREIGN PRACTICE OF VOCATIONAL AND CAREER DEVELOPMENT OF CIVIL SERVANTS
Вестник университета, 2016 The article presents the analysis of foreign experience in the field of vocational and career development of civil servants. It is shown that the basis for professional and career growth of civil servants lies with the dominant model of civil service ...
A. Suvorov
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Semnul ca entitate fractală în concepția lui C.S. Peirce [PDF]
EonThis essay aims to revisit C.S. Peirce's semiotic project within an interdisciplinary framework shaped by some speculative and terminological acquisitions from fractal geometry.
Cristian PAȘCALĂU
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source