Results 121 to 130 of about 5,416,136 (295)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Russian Journal of Economics and Law, 2008 The article views the notion of objective part of corpus delicti and proves the high social threat of ecological crimes. The author suggests to combine all the functioning environmental regulations into one normative legal act, which would regulate the ...
A. Zartdinova
doaj
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
CRIMES AGAINST FAMILY AND NON-ADULTS IN THE SYSTEM OF SPECIAL PART OF THE RUSSIAN CRIMINAL LAW
Russian Journal of Economics and Law, 2007 The work presents juridical analysis of the corpus delicti included into Chapter 20 of the Russian Federation Criminal Law. It gives the author's viewpoints concerning the objects, objective parts, subjective parts and subjects of the mentioned crimes.
N. N. Marshakova
doaj
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
FOREIGN PRACTICE OF VOCATIONAL AND CAREER DEVELOPMENT OF CIVIL SERVANTS
Вестник университета, 2016 The article presents the analysis of foreign experience in the field of vocational and career development of civil servants. It is shown that the basis for professional and career growth of civil servants lies with the dominant model of civil service ...
A. Suvorov
doaj
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Semnul ca entitate fractală în concepția lui C.S. Peirce [PDF]
EonThis essay aims to revisit C.S. Peirce's semiotic project within an interdisciplinary framework shaped by some speculative and terminological acquisitions from fractal geometry.
Cristian PAȘCALĂU
doaj
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source