Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The Comparison of Human and Machine Performance in Object Recognition. [PDF]
Kul G, Wills AJ.
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Visual classification of allergenic pollen in iteratively reconstructed lens-less DIHM images. [PDF]
Cugmas B +5 more
europepmc +1 more source
Agreement vs. case marking and direct objects
This paper discusses universal tendencies of agreement and case marking with particular reference to direct objects.
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Tomato Multi-Angle Multi-Pose Dataset for Fine-Grained Phenotyping. [PDF]
Zhang Y +3 more
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
A semi-automated imaging and analysis pipeline for NET quantification and temporal-profiling of NETosis. [PDF]
Landry C +4 more
europepmc +1 more source
OBJECT - VERB AGREEMENT IN QUECHUA
この論文はアンデス山脈に住んでいる原住民族,すなわち古代のインカ帝国の言語ケチュワ語の動詞の形態構造を記述し,その中の動詞と目的語の一致が,最近のアメリカ言語学における動詞の屈折に関する機能主要部移動をもって説明しようとする理論に対して説明が不十分であると主張する。 This paper describes verb morphology in Quechua, and argues that verb-object agreement poses a challenge to recent attempts to account for verb inflection in terms of movement through a series of functional head ...
openaire

