Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Instance mask alignment for object detection knowledge distillation. [PDF]
Guo Z, Zhang P, Liang P.
europepmc +1 more source
MCD-Net: Robust Multi-UAV Cooperative Detection via Secondary Matching and Hybrid Fusion for Occluded Objects [PDF]
Huijie Zhou +5 more
openalex +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Garlic-YOLO-DD: a lightweight object detection algorithm for garlic damage detection. [PDF]
Gao Y +6 more
europepmc +1 more source
Improving the Traffic Sign Object Detection Algorithm of Yolov8
wentao li, Huan Lao, Xinwen Xie, J. Liu
openalex +1 more source
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Robust Object Detection in Adverse Weather Conditions: ECL-YOLOv11 for Automotive Vision Systems. [PDF]
Liu Z, Zhang J, Zhang X, Song H.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Rotation-Sensitive Feature Enhancement Network for Oriented Object Detection in Remote Sensing Images. [PDF]
Xu J, Huo H, Kang S, Mei A, Zhang C.
europepmc +1 more source

