Results 41 to 50 of about 544,930 (344)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Conscientious objection as structural violence in the voluntary termination of pregnancy in Chile

Frontiers in Psychology, 2022
IntroductionAfter three decades of the absolute prohibition of abortion, Chile enacted Law 21,030, which decriminalizes voluntary pregnancy termination when the person is at vital risk, when the embryo or fetus suffers from a congenital or genetic lethal
Adela Montero, Mirliana Ramirez-Pereira, Paz Robledo, Lidia Casas, Lieta Vivaldi, Daniela Gonzalez   +5 more
doaj   +1 more source

Epistemic Schmagency? [PDF]

, 2018
Constructivist approaches in epistemology and ethics offer a promising account of normativity. But constructivism faces a powerful Schmagency Objection, raised by David Enoch.
Flowerree, A. K.
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The right to decide of the minor patients

Revista Colombiana de Bioética, 2019
The object of study in this article is to analyze the complex situation that arises in the sanitary field when a minor declines medical treatment for religious, ideological or any other reasons.
Juan Manuel Alba Bermúdez
doaj   +1 more source

An ethical issue: nurses’ conscientious objection regarding induced abortion in South Korea

BMC Medical Ethics, 2020
Background The Constitutional Court of South Korea declared that an abortion ban was unconstitutional on April 11, 2019. The National Health Care System will provide abortion care across the country as a formal medical service. Conscientious objection is
Chung Mee Ko, Chin Kang Koh, Ye Sol Lee
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Arap Dilinde Kıyâs Meʿa’l-Fârık

Tokat İlmiyat Dergisi
Nahiv usûlü ilminde dilde ortak illet nedeniyle menkûl olmayanı (makîs/ferʿ) menkûl olana (makîsun aleyh/asl) hamletmek olarak tanımlan kıyas, hem mütekaddim hem de müteahhir nahiv âlimleri tarafından vazgeçilmez bir yöntem olarak ele alınmıştır.
Abdulkadir Kişmir
doaj   +1 more source

Legal remedies in the new law on general administrative procedure [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2017
Although the new Law on General Administrative Procedure of 2016, which has become fully applicable in June 1, 2017, abounds with novelties considering the legal remedies, it can be said that the actual level of legal protection of the parties in the ...
Lončar Zoran J.
doaj  

Moral Hedging and Responding to Reasons [PDF]

, 2019
In this paper, I argue that the fetishism objection to moral hedging fails. The objection rests on a reasons-responsiveness account of moral worth, according to which an action has moral worth only if the agent is responsive to moral reasons. However, by
Hicks, Amelia
core