Results 41 to 50 of about 537,875 (314)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

What is the Incoherence Objection to Legal Entrapment? [PDF]

, 2022
Some legal theorists say that legal entrapment to commit a crime is incoherent. So far, there is no satisfactorily precise statement of this objection in the literature: it is obscure even as to the type of incoherence that is purportedly involved ...
Hill, Daniel, McLeod, Stephen K., Tanyi, Attila   +2 more
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Evaluation of Health Board Documents Referred to the Tertiary Hospital for Objection and Referral in Terms of Ophthalmology

Hamidiye Medical Journal
Background: Medical board examinations and scoring form a substantial part of the workload for specialized physicians in Türkiye. This study evaluates these tasks from the perspective of ophthalmology specialists and compares the ophthalmologic ...
Mehmet Egemen Karataş, Gamze Karataş
doaj   +1 more source

The missing voices in the conscientious objection debate: British service users’ experiences of conscientious objection to abortion

BMC Medical Ethics, 2023
Background The fourth section of the 1967 Abortion Act states that individuals (including health care practitioners) do not have to participate in an abortion if they have a conscientious objection.
Becky Self, Clare Maxwell, Valerie Fleming   +2 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

An Examination of the Wisdoms of Abrogation (Naskh) in the Holy Qur’an

مجلۀ علمی-تحقیقی سمنگان
The discussion of abrogation (naskh), in addition to jurisprudence (fiqh) and the principles of jurisprudence (usul al-fiqh), is regarded as one of the significant branches of Qur’anic sciences.
Mehrabuddin shahab
doaj   +1 more source

The Deadline for Invoking the Frivolous Claim in Iranian Law (Looking at the Judicial Procedure) [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i Khuṣūṣī
The demand for security for damages resulting from filing a false lawsuit is an institution to counter baseless and harassing lawsuits, which has also been considered by the Iranian legislator.
Mahdi Hamze Howeyda
doaj   +1 more source

Siting prisons, sighting communities: geographies of objection in a planning process [PDF]

, 2014
This paper reviews the planning process for a Scottish prison located near a former mining village. Analysing the letters of objection submitted by residents offers an opportunity to explore local views about prison and community and to relate these to ...
Apthorpe R, Barry J, Clifford J, Davis A, Flyvberg B, Frisby D, Good A, Hartland R, Legg CJ, Redwood, Reed A, Shore C, Simmel G, Smith H, Stone D, West Lothian Council   +15 more
core   +1 more source