Results 181 to 190 of about 22,537,611 (357)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Association between objectively measured, multidimensional sleep health and cognitive function in older adults: cross-sectional wearable tracker study

Shuo Qin, Kwun Kei Ng, Chun Siong Soon, Xin Yu Chua, Juan Zhou, Woon‐Puay Koh, Michael W.L. Chee   +6 more
openalex   +1 more source

Optimal Solution of Vehicle Routing Problems with Fractional Objective\n Function [PDF]

, 2018
Roberto Baldacci, Andrew E. B. Lim, Emiliano Traversi, Roberto Wolfler Calvo   +3 more
openalex   +1 more source

Investigation of influence of objective function valley ratio on the determination error of its minimum coordinates

, 2023
A. V. Smirnov
openalex   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

An Auxiliary Hybrid Heuristic Approach for Objective Function Design Evaluation-Using Train Unit Scheduling as an Example. [PDF]

SN Oper Res Forum
Lei L, Kwan R, Lin Z.
europepmc   +1 more source

Comparative evaluation of normal tissue objective functions in robotic radiosurgery planning for solitary brain tumors [PDF]

Nadine Sonntag, Markus Eichner, Michael Judge, Martin Köcher, Daniel Rueß, Maximilian I. Ruge, Stefan Hunsche   +6 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Flood Algorithm-Tuned PID-F Controller with a Modified Objective Function for Robust and Noise-resilient Speed Control of Nonlinear SparkIgnition Engines. [PDF]

Sci Rep
Ekinci S, Izci D, Turkeri C, Bajaj M, Rubanenko O.   +4 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source