Results 141 to 150 of about 1,415,527 (319)
Storage and manipulation of vague spatial objects using existing GIS functionality
, 2006 We collect and store data to derive information and make judgments about a world of our interest. Ideally, they should indicate in a unique and certain way which possible world corresponds to the actual world [17].
Dilo, A. +3 more
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
FRAMEWORK FOR FLEXIBLE REUSE AND ASSEMBLY OF LEARNING OBJECTS – A PILOT PROJECT [PDF]
The present paper aims to highlight certain relevant and new features revealed by the research on assisted training. The motivation is given by the necessity to efficiently develop the educational resources by combining reusable learning objects, and ...
Justina Lavinia Stănică +1 more
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Objects, Thin Objects, Thin Access to Objects
Deflationist approaches to abstract objects typically have a distinctive advantage over non-deflationist counterparts on the epistemological front, given the avoidance of commitment to the existence of these objects (Azzouni, Deflating existential ...
Bueno, Otávio
core +1 more source
Cooperatively Augmenting Smart Objects with Projector-Camera Systems [PDF]
, 2006 In this paper we propose an object-centric method of augmenting mobile smart objects using projection onto the surface of the objects. We assume that the objects are both real world objects with an inherent use, and autonomous computational nodes that ...
Molyneaux, David +3 more
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
An innovative use of learning objects and learning style in pedagogic agent systems [PDF]
, 2005 Adaptivity in education is increasingly demanded in order to improve the efficiency and effectiveness of the learning process, but few intelligent learning systems exist which are dynamic and able to provide personalized learning materials to satisfy ...
Sun, Shanghua +2 more
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