Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Retention and Completion of a Doctoral Nursing Programme: Sense Making Through Collective Reflection. [PDF]
Bassett S +3 more
europepmc +1 more source
Incoterms 2010 and the mode of transport: how to choose the right term [PDF]
Malfliet, Jonas
core +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
The Lesson of Sleeping Beauty: Person-Centred Care for the Unconscious, Unresponsive ICU Patient in the Face of Levinas' Radical Alterity. [PDF]
Clement T +3 more
europepmc +1 more source
[The obligation to refer--one more time].
openaire +1 more source
CONFLICTING ROLE OBLIGATIONS AND ROLE TYPES : With A Special Reference To Race Relations
openaire +2 more sources
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Beneficence-Based Obligations and Ethics Consultation in Assisted Dying. [PDF]
Marckmann G, Hirsch A.
europepmc +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source

