Results 71 to 80 of about 7,735 (284)

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Interhemispheric connections between olfactory bulbs improve odor detection.

PLoS Biology, 2020
Interhemispheric connections enable interaction and integration of sensory information in bilaterian nervous systems and are thought to optimize sensory computations.
Florence Kermen, Pradeep Lal, Nicholas G Faturos, Emre Yaksi   +3 more
doaj   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Enhanced Congestion Management for Minimizing Network Performance Degradation in OBS Networks

SAIEE Africa Research Journal, 2018
Current global data traffic is increasingly dominated by delay and loss intolerant IP traffic which generally displays a structural self-similarity. This has necessitated the introduction of optical burst switching (OBS) as a supporting optical backbone network switching technology. Due to the buffer-less nature of optical burst switched (OBS) networks,
Nleya, Bakhe, Mutsvangwa, Andrew
openaire   +3 more sources

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

PRUNED ANN MODEL FOR THREE PHASE INDUCTION MOTOR OPERATING CONDITIONS CLASSIFICATION

Diyala Journal of Engineering Sciences, 2008
The Artificial Neural Networks (ANN) have become a very useful tool in a wide range of engineering applications. In this paper, feed forward neural network Optimal Brain Surgeon (OBS) pruned model is proposed to classify the operating conditions of ...
Ali Khudhair Mutlag
doaj   +1 more source

Group Scheduling for MultiChannel in OBS Networks

REV Journal on Electronics and Communications, 2014
Group scheduling is a scheduling operation of optical burst switching networks in which the burst header packets arriving in each timeslot will schedule their following bursts simultaneously. There have been many proposals for group scheduling (such as OBS-GS, MWIS-OS and LGS), but they consider mainly to schedule the arriving bursts which have the ...
Nguyen Hong Quoc, Vo Viet Minh Nhat, Nguyen Hoang Son   +2 more
openaire   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program

Nutrition & Metabolism, 2005
Background The Family Blood Pressure Program is an ongoing, NHLBI-sponsored, multi-center program to study the genetic determinants of high blood pressure.
Quertermous Thomas, Hsiung Chao, Turner Stephen T, Mosley Thomas H, Weder Alan B, Rao DC, Kraja Aldi T, Cooper Richard, Curb J David, Province Michael A   +9 more
doaj   +1 more source