Results 121 to 130 of about 689,003 (332)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Automation in Middle- and Upper-Atmosphere LIDAR Operations: A Maximum Rayleigh Altitude Prediction System Based on Night Sky Imagery

Remote Sensing
A prediction system was developed to determine the maximum Rayleigh altitude (MRA) by improving the automated detection of LIDAR power-on conditions and adapting to advancements in middle- and upper-atmosphere LIDAR technology.
Junfeng Wei, Linmei Liu, Xuewu Cheng, Yi Fan, Weiqiang Zhan, Lifang Du, Wei Xiong, Zhaoxiang Lin, Guotao Yang   +8 more
doaj   +1 more source

Medication errors in neonatal intensive care unit of a tertiary care hospital in South India: A prospective observational study

, 2020
Padmini Devi, BPrakadeesh Bharathi, Jeffrey Pradeep Raj, Kevin Saldanha, PN Suman Rao   +4 more
openalex   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Evaluating The Accuracy of Gridded Climate Datasets for Precipitation, Surface Air Temperature, and Sea Surface Temperature in Central Java, Indonesia

Indonesian Journal of Applied Physics
Studies of climate information that rely on accurate and reliable data are essential in hydrometeorological monitoring, early warning, and climate change impacts in areas with varied topography and limited observation data, such as Central Java ...
Iis Widya Harmoko, Muhammad Zainuri, Anindya Wirasatriya, Supari Supari   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The observation range adjusted method: a novel approach to accounting for observation uncertainty in model evaluation

Environmental Research Communications
Model evaluations are performed by comparing a modelled quantity with an observation of that quantity and any deviation from this observed quantity is considered an error.
J P Evans, H M Imran
doaj   +1 more source

Rainfall Prediction Using Integrated Machine Learning Models With K-Means Clustering: A Representative Case Study of Harirud Murghab Basin-Afghanistan

IEEE Access
Accurate rainfall prediction was essential for effective water resource management and disaster preparedness, especially in regions with limited observational data such as Afghanistan.
Ziaul Haq Haq Doost, Ali Alsuwaiyan, Abdulazeez Abdulraheem, Nabil M. Al-Areeq, Zaher Mundher Yaseen   +4 more
doaj   +1 more source

Direct Observation Approach for Medication Errors Detection in an Educational Hospital

, 2022
Armin Pourhosseiny, Mohammad Hossein Dehqani, Adeleh Sahebnasagh, Farnoosh Mirjalili, Fatemeh Saghafi   +4 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source