Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Power Spectra of Physics‐Based and Data‐Driven Ensembles
Meteorological ApplicationsPower spectra are evaluated for a range of ensemble systems run at the European Centre for Medium‐Range Weather Forecasts (ECMWF). These spectra allow us to chart and compare the spatial–temporal evolution of ensemble spread and error, and to evaluate ...
Mark J. Rodwell +4 more
doaj +1 more source
Impact of RT-7.5 Radio Telescope Driver Tracking Errors on the Sun Observation Accuracy
, 2016 V. S. Ryzhov, D Dimiyev, N. A. Jarkova
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Systematic errors in estimates of $R_t$ from symptomatic cases in the presence of observation bias [PDF]
, 2020 Guido Sanguinetti
openalex
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
21cmlstm: A Fast Memory-based Emulator of the Global 21 cm Signal with Unprecedented Accuracy
The Astrophysical JournalNeural network (NN) emulators of the global 21 cm signal need an emulation error much less than the observational noise in order to be used to perform unbiased Bayesian parameter inference.
J. Dorigo Jones +4 more
doaj +1 more source
Impacts of Assimilating GOES‐16 ABI Channels 9 and 10 Clear Air and Cloudy Radiance Observations With Additive Inflation and Adaptive Observation Error in GSI‐EnKF for a Case of Rapidly Evolving Severe Supercells [PDF]
, 2022 Aaron Johnson +2 more
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