Results 81 to 90 of about 689,003 (332)

dotears: Scalable and consistent directed acyclic graph estimation using observational and interventional data

iScience
Summary: New assays such as Perturb-seq link parallel CRISPR interventions to transcriptomic readouts, providing insight into gene regulatory networks.
Albert Xue, Jingyou Rao, Sriram Sankararaman, Harold Pimentel   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Systematic Continuum Errors in the Lyman-Alpha Forest and The Measured Temperature-Density Relation

, 2012
Continuum fitting uncertainties are a major source of error in estimates of the temperature-density relation (usually parametrized as a power-law, $T \propto \Delta^{\gamma - 1} $) of the inter-galactic medium (IGM) through the flux probability ...
Becker, Cen, Croft, Croft, Dall’Aglio, Davé, Faucher-Giguère, Faucher-Giguère, Furlanetto, Hui, Khee-Gan Lee, McDonald, McDonald, McQuinn, Miralda-Escudé, Miralda-Escudé, Scott, White, Zaldarriaga   +18 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Quantifying UAS Observation Error Variance Used in Data Assimilation Systems and Its Impact on Predictive Skill

Journal of Advances in Modeling Earth Systems
Observation error determines the weights of the observations and background state used in data assimilation to generate analyses. Quantifying observation error is critical for the optimal assimilation of observational data sets. Uncrewed Aircraft System (
J. Kay, J. O. Pinto, T. M. Weckwerth, G. deBoer   +3 more
doaj   +1 more source

Linear Meta-Model optimization for regional climate models (LiMMo version 1.0) [PDF]

Geoscientific Model Development
A new tool for objective parameter tuning of regional climate models is presented. The climate model output was emulated using a linear regression approach for each grid point on a monthly mean basis. This linear approximation showed decent accuracy over
S. Petrov, A. Will, B. Geyer
doaj   +1 more source

Power of Observational Hubble Parameter Data: a Figure of Merit Exploration

, 2011
We use simulated Hubble parameter data in the redshift range 0 \leq z \leq 2 to explore the role and power of observational H(z) data in constraining cosmological parameters of the {\Lambda}CDM model.
Ma, Cong, Zhang, Tong-Jie
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

A Prospective Open‐Label Observational Study of a Buffered Soluble 70 mg Alendronate Effervescent Tablet on Upper Gastrointestinal Safety and Medication Errors: The GastroPASS Study [PDF]

, 2021
Salvatore Minisola, Antônio Pedro Vargas, Giulia Letizia Mauro, Fernando Bonet Madurga, Giovanni Adami, Dennis M. Black, Nawab Qizilbash, Josep Blanch‐Rubió   +7 more
openalex   +1 more source